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6th December 2008 - New research THE LIKELIHOOD OF TOXICITY CAUSING PARKINSON'S DISEASE Journal of Agromedicine [2008] 13 (1) : 37-48 (Dhillon AS, Tarbutton GL, Levin JL, Plotkin GM, Lowry LK, Nalbone JT, Shepherd S.) Complete abstract There are a number of toxic substances that are known to cause Parkinson's Disease. For more information go to Toxic causes of Parkinson's Disease. Toxicity can cause Parkinson's Disease on its own, or can make Parkinson's Disease more likely if combined with other factors. Toxicity can initiate Parkinson's Disease, and then lead to persistent Parkinson's Disease because of the after effect of drugs needed to treat it, even when the toxic effect has worn off. Toxicity can often be reversed by avoiding the toxic substance. However, with some toxins this can take years because the toxin can accumulate in the blood and in the brain. Toxicity is often claimed to be the main cause of Parkinson's Disease, but the evidence indicates that toxicity causes Parkinson's Disease only in a minority of cases. It has not previously been known how readily various toxins can cause Parkinson's Disease. This study evaluated the risk of causing Parkinson's Disease after exposure to a variety of toxins. Rotenone, a pesticide, was found to massively increase the risk of Parkinson's Disease, even when used when only during the past year doing gardening. Any use at all of rotenone in the past made Parkinson's Disease far more likely. Of those substances assessed, the next most likely to cause Parkinson's Disease were, in order : work in a paper / lumber mill, exposure to cadmium, past work in an electronics plant, insecticide applications to animal areas and agricultural processes, paraquat (the herbicide), exposure to fluorides (used in industry), and least of all, the use of chlorpyrifos products (insecticides). Cigarette smoking, alcohol use, and fish intake were associated with a reduced risk. Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn