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I have been on the same drug regimen for the last 12 years and it controls my symptoms for the most part. I take my carbidopa levedopa 25/100 4x a day; at 8 AM, 11:30 AM, 3 PM and 6:30 PM. For the last several months I have been taking another dose one half hour before bedtime. This really seems to help me sleep, mainly because I'm not doing battle with my blankets etc, etc. The comment about food (especially protein) to close too your dose reducing the drugs effectiveness is very much true. I also take... Amantadine (100 Mg 2X per day) Requip (4Mg 4X per day) Comtan (200 Mg 4X per day) For whatever reason, my version of PD has progressed slowly and so far I'm not too bad off in terms of dyskinesia and bradykinesia as side effects of the carbidopa levadopa. When I'm off I really struggle with tightening muscles, slow movement, pill rolling hands, and fatigue to name a few symptoms off the list. I had to weigh the potential side effects versus the opportunity to spend quality time with wife and two boys. I choose to take the drug and deal with the side effects as they happen. hope you're doing well, Scott Burnett 7715 Heather Dr. Stockton, CA 95297 209-478-9328 [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn