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Thomson Financial News
UPDATE 2-Merck KGaA says drug helps Parkinson's patients
02.03.09, 08:19 AM EST
FRANKFURT, Feb 3 (Reuters) - A late-stage study has shown Merck KGaA's 
experimental Parkinson's treatment safinamide, when taken with standard drug 
levodopa, improves patients' motor functions, the German group said on 
Tuesday.
The pill, developed jointly with Italian biotech company Newron, extended 
the time when Parkinson's patients experienced their best level of body 
control in the last of three stages of testing usually required for 
regulatory approval, the company said in a statement.
Patients receiving levodopa with safinamide experienced more than half an 
hour longer periods of good motor control per day than those receiving 
levodopa with a placebo.
In addition, the safinamide-treated group saw an improvement of 1.3 hours 
per day from before the start of the drug regimen.
The compound is being tested in two more Phase III trials, the company said.
'Efficacy-wise this is at best comparable to currently available drugs,' 
WestLB analysts wrote in a note to investors, saying caution is warranted 
until further results emerge.

Merck (nyse: MRK - news - people ) shares firmed 0.5 percent to 66.85 euros 
by 1230 GMT, while the European DJ Stoxx Health Care Index edged up 0.6 
percent.

Shares in Zurich-listed Newron were down 5.6 percent at 21 Swiss francs, 
after initially gaining 16.6 percent at the open.
Commerzbank analyst Daniel Wendorff said he kept his projection of peak 
sales of 500 million euros for the drug unchanged, awaiting results from the 
remaining Phase III trials before reconsidering his assessment.
His appraisal of Merck's value is based on a 50 percent chance of approval 
for the pill.
Kepler analyst Florian Gaiser was more upbeat.
'The addressable market has doubled with the result and we are more 
confident with our sales forecast of over 400 million euros some time beyond 
2017.'

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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