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 PARKINSON'S DISEASE NEWS
from Viartis

24th March 2009 - New research
THE DISCOVERY OF HOW DEEP BRAIN STIMULATION AFFECTS PARKINSON'S DISEASE

Science [2009] Mar 19. [Epub ahead of print] (Gradinaru V, Mogri M, Thompson 
KR, Henderson JM, Deisseroth K.)  Complete abstract

Deep brain stimulation (DBS) is a method of treating Parkinson's Disease 
that involves the use of electrodes that are implanted into the brain and 
connected to a small electrical device that can be externally programmed. 
DBS is able to reduce the need for Parkinson's Disease drugs. For more 
information go to Deep brain stimulation. It has always been uncertain as to 
how DBS has such a strong effect on Parkinson's Disease. Researchers used 
light to illuminate how the treatment works. They had suspected that brain 
cells are stimulated or calmed, leading to reduced Parkinson's Disease 
symptoms. Yet when they tried every type of brain cell they found that DBS 
had no direct effect on them. It was instead found that the effect occurs, 
not by stimulating cells, but by stimulating axons.  Axons are what connect 
nerve cells to other nerve cells, as can be seen in the diagram. Axons can 
be more than a metre (several feet) in length. For more information go to 
Axons. For more information go to the complete News report. The effect of 
artificially stimulating brain cells can wear off in time, but so can 
artificially stimulating axons as it is now known occurs with DBS.


Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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