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Hi Rick, I am not a doctor of medicine, and the following is not medical advice, but only the personal opinion of the writer. Any contemplated change in treatment or medication must be referred to your treating medical practioner. There is an excellent paper on constipation generally, at http://www.betterhealth.vic.gov.au/BHCV2/BHCARTICLES.NSF/pages/Constipation?OpenDocument There is another good paper on constipation in PD at http://www.betterhealth.vic.gov.au/BHCV2/BHCARTICLES.NSF/pages/Constipation?OpenDocument Both are produced by the state health department of Victoria, Australia. There is a much more technical paper on the subject of drug delivery through the digestive system at http://72.14.235.132/search?q=cache:XA-jmHD6IDgJ:e-jst.teiath.gr/issue_11_2009/Putheti_11.pdf+motility+chime&cd=4&hl=en&ct=clnk&gl=au&client=firefox-a I hate to "cop-out" at this stage, but I will have to leave you to your own devices at the moment. The constipation question has not altered in the ten or so years that I last addressed it here, so I am thinking it is perhaps time I visited the problem again, at length. Just consider this for the moment: anything that delays the passage of food through the digestive system has the propensity to affect adversely the delivery of drugs, as do the temperature, quantity and acidity of accompanying liquids. Standard methods of dealing with constipation are for otherwise normal people, and not for PWP. Keep the volume, keep it wet, keep it moving. And good luck! ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn