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Scripps Claims Breakthrough in Stem Cells

Researchers at The Scripps Research Institute have discovered a new way to 
convert adult stem cells back to an embryonic-like state -- a breakthrough 
that they say will lead to advanced therapies for a range of illnesses from 
diabetes to Parkinson's disease.

There has been a race in recent years among stem-cells researchers to 
develop methods to take an adult cell, like a skin cell, and essentially 
reprogram it so it has the same properties as embryonic cells. If 
researchers could make this happen, then medical science could use stem 
cells to work towards curing illnesses while avoiding the controversial 
issues that surround embryonic stem cells.
However, safely accomplishing this conversion has proven to be extremely 
difficult, the problem being that when the cells are converted back they 
become genetically altered, which creates a host of problems.

The Scripps researchers, who partnered with local companies and the Max 
Planck Institute for Molecular Biomedicine in Germany, say they found a way 
to avoid the genetic manipulations by using recombinant proteins, proteins 
made from the recombination of fragments of DNA from different organisms. 
This, they say, allows them to gradually reprogram cells without altering 
the genes.

"We are very excited about this breakthrough," said Sheng Ding, an associate 
professor at Scripps. "Scientists have been dreaming about this for years."

-- DAVID WASHBURN

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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