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gee, I didn't know milk thistle would help my liver produce dopamine. I started taking it for constipation. Do I need to take tyrosine with it? Ray Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] -------------------------------------------------- From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> Sent: Tuesday, May 05, 2009 8:40 AM To: <[log in to unmask]> Subject: Question re Amantadine/ GSH importance > Couple of thoughts. > Have you tried to let your liver produce your dopamine needs by taking > tyrosine and milk thistle? > The natural production of GSH by the body is a little more complicated > but > following is article from my archives that helps explain. > WHY GSH > Oxidative stress appears to play an important role in degeneration of > dopaminergic neurons of the substantia nigra (SN) associated with > Parkinson's disease (PD). The SN of early PD patients have dramatically > decreased levels of the thiol tripeptide glutathione (GSH). GSH plays > multiple roles in the nervous system both as an antioxidant and a redox > modulator. We have generated dopaminergic PC12 cell lines in which levels > of > GSH can be inducibly down-regulated via doxycycline induction of antisense > messages against both the heavy and light subunits of > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in > glutathione > synthesis. Down-regulation of glutamyl-cysteine synthetase results in > reduction in mitochondrial GSH levels, increased oxidative stress, and > decreased mitochondrial function. Interestingly, decreases in > mitochondrial > activities in GSH-depleted PC12 cells appears to be because of a selective > inhibition of complex I activity as a result of thiol oxidation. These > results suggest that the early observed GSH losses in the SN may be > directly > responsible for the noted decreases in complex I activity and the > subsequent > mitochondrial dysfunction, which ultimately leads to dopaminergic cell > death > associated with PD. > > WHY GLUTAMINE > Glutamine is an important mitochondrial substrate implicated in the > protection of cells from oxidant injury. Human pulmonary epithelial-like > (A549) cells were exposed to 95% O(2) for 4 days in the absence and > presence > of glutamine. Cell proliferation in normoxia was dependent on glutamine, > and > glutamine deprivation markedly accelerated cell death in hyperoxia. > Glutamine significantly increased cellular ATP levels in normoxia and > prevented the loss of ATP in hyperoxia seen in glutamine-deprived cells. > Mitochondrial membrane potential as assessed by flow cytometry with > chloromethyltetramethylrosamine was increased by glutamine in > hyperoxia-exposed A549 cells, and a glutamine dose-dependent increase in > mitochondrial membrane potential was detected. Glutamine-supplemented, > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and GSH > content. > Electron and fluorescence microscopy revealed that, in hyperoxia, > glutamine > protected cellular structures, especially mitochondria, from damage. In > hyperoxia, activity of the tricarboxylic acid cycle enzyme > alpha-ketoglutarate dehydrogenase was partially protected by its indirect > substrate, glutamine, indicating a mechanism of mitochondrial protection. > THEREFORE: I take L-Glutamine and DHEA to increase the level of GSH in > the > body naturally to further thwart the symptoms and destruction of P.D. > along > with my other vitamin/mineral protocol which exclude PD drugs. As a note. > I > never tried the Amantadine. My doctors forced me early to look elsewhere > for > help since they couldnt due to lack of knowledge or incentive. Not sure > which but I'm alot healthier for switching to a no drug protocol. > > ----- Original Message ----- > From: "Ernesto Divo" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Sunday, May 03, 2009 12:24 PM > Subject: Re: Question re Amantadine use > > >> Hi John, >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect and >> Requip (Ropinirole) the nausea form the Requip is unbearable. I have >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a > supplement >> developed here in the US, by a US scientist and sold by a US >> company. It raises thet levels of GSH in your cells naturally. It took >> the >> GXL about a week to work on my sleeping pattern, I was waking up 2-3 >> times >> during the night, now I sleep straight thru the night, and it took about >> three weeks to work on my cognitive process but it was so subtle I barely >> thought it was the GXL. I wasn't having problems looking for words to > finish >> a sentence, my memory is back, I don't lose things around the house, I > have >> more energy and I feel good and my wife is happier. It is strange, when >> I >> asked my doctor about it he said Gluta what? it seems the medical > community >> is keeping the use of Glutathione (GSH) under wraps, they don't want >> competition... I order mine from www.maxgxl.com/133282 I suggest >> getting >> as much info as possible of GSH, I went to www.youtube.com and searched > for >> 'The mother of all antioxidants', there is this doctor Mark Hyman who >> explains in details about GSH; excellent video. >> >> Good luck to you. >> >> Ernesto, >> Miami, FL >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys <[log in to unmask]> > wrote: >> >> > Hey John >> > >> > I've been on Amantadine since being diagnosed in October of last year; >> > dosage has remained constant and titrated from 100mg to 300mg per day, > over >> > an initial period of 3 weeks. >> > >> > I space the dosing about 5-ish hours apart; I've found if the final >> > dose > of >> > 100mg is taken later than 8PM, I have trouble sleeping through the > night. >> > >> > It does give me an energy boost and some minor relief from muscle >> > tightness, but does nothing to improve gait or reduce tremor. It's sort > of >> > just a little bit of "gas" for your "engine." >> > >> > On the other hand, I find it causes auditory hallucinations, >> > drowsiness, >> > occasional vertigo, foggy thought processing and swelling around the > knees. >> > >> > I find much better results on GSH and mucuna bean, which I started >> > about > 6 >> > months ago (the mucuna has been a very recent thing, so it's been too > early >> > to tell – but so far, I'm definitely impressed). My neuro practically > lit >> > his own hair on fire when I told him, but he couldn't deny the results > of >> > the GSH. >> > >> > The goal is to be able to cut the amantadine by 35 - 50% within 6 > months. >> > My view is the longer I stay away from starting the agonists, the > better. >> > >> > Hope that helps. >> > >> > >> > >> > Joh >> > >> > >> > ---------------------------------------------------------------------- >> > To sign-off Parkinsn send a message to: mailto: >> > [log in to unmask] >> > In the body of the message put: signoff parkinsn >> > >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: > mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn