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Yep! ----- Original Message ----- From: "rayilynlee" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, May 05, 2009 9:45 AM Subject: Re: Question re milk thistle > gee, I didn't know milk thistle would help my liver produce dopamine. I > started taking it for constipation. Do I need to take tyrosine with it? > > Ray > > Rayilyn Brown > Director AZNPF > Arizona Chapter National Parkinson Foundation > [log in to unmask] > > -------------------------------------------------- > From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> > Sent: Tuesday, May 05, 2009 8:40 AM > To: <[log in to unmask]> > Subject: Question re Amantadine/ GSH importance > > > Couple of thoughts. > > Have you tried to let your liver produce your dopamine needs by taking > > tyrosine and milk thistle? > > The natural production of GSH by the body is a little more complicated > > but > > following is article from my archives that helps explain. > > WHY GSH > > Oxidative stress appears to play an important role in degeneration of > > dopaminergic neurons of the substantia nigra (SN) associated with > > Parkinson's disease (PD). The SN of early PD patients have dramatically > > decreased levels of the thiol tripeptide glutathione (GSH). GSH plays > > multiple roles in the nervous system both as an antioxidant and a redox > > modulator. We have generated dopaminergic PC12 cell lines in which levels > > of > > GSH can be inducibly down-regulated via doxycycline induction of antisense > > messages against both the heavy and light subunits of > > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in > > glutathione > > synthesis. Down-regulation of glutamyl-cysteine synthetase results in > > reduction in mitochondrial GSH levels, increased oxidative stress, and > > decreased mitochondrial function. Interestingly, decreases in > > mitochondrial > > activities in GSH-depleted PC12 cells appears to be because of a selective > > inhibition of complex I activity as a result of thiol oxidation. These > > results suggest that the early observed GSH losses in the SN may be > > directly > > responsible for the noted decreases in complex I activity and the > > subsequent > > mitochondrial dysfunction, which ultimately leads to dopaminergic cell > > death > > associated with PD. > > > > WHY GLUTAMINE > > Glutamine is an important mitochondrial substrate implicated in the > > protection of cells from oxidant injury. Human pulmonary epithelial-like > > (A549) cells were exposed to 95% O(2) for 4 days in the absence and > > presence > > of glutamine. Cell proliferation in normoxia was dependent on glutamine, > > and > > glutamine deprivation markedly accelerated cell death in hyperoxia. > > Glutamine significantly increased cellular ATP levels in normoxia and > > prevented the loss of ATP in hyperoxia seen in glutamine-deprived cells. > > Mitochondrial membrane potential as assessed by flow cytometry with > > chloromethyltetramethylrosamine was increased by glutamine in > > hyperoxia-exposed A549 cells, and a glutamine dose-dependent increase in > > mitochondrial membrane potential was detected. Glutamine-supplemented, > > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and GSH > > content. > > Electron and fluorescence microscopy revealed that, in hyperoxia, > > glutamine > > protected cellular structures, especially mitochondria, from damage. In > > hyperoxia, activity of the tricarboxylic acid cycle enzyme > > alpha-ketoglutarate dehydrogenase was partially protected by its indirect > > substrate, glutamine, indicating a mechanism of mitochondrial protection. > > THEREFORE: I take L-Glutamine and DHEA to increase the level of GSH in > > the > > body naturally to further thwart the symptoms and destruction of P.D. > > along > > with my other vitamin/mineral protocol which exclude PD drugs. As a note. > > I > > never tried the Amantadine. My doctors forced me early to look elsewhere > > for > > help since they couldnt due to lack of knowledge or incentive. Not sure > > which but I'm alot healthier for switching to a no drug protocol. > > > > ----- Original Message ----- > > From: "Ernesto Divo" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Sunday, May 03, 2009 12:24 PM > > Subject: Re: Question re Amantadine use > > > > > >> Hi John, > >> > >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect and > >> Requip (Ropinirole) the nausea form the Requip is unbearable. I have > >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a > > supplement > >> developed here in the US, by a US scientist and sold by a US > >> company. It raises thet levels of GSH in your cells naturally. It took > >> the > >> GXL about a week to work on my sleeping pattern, I was waking up 2-3 > >> times > >> during the night, now I sleep straight thru the night, and it took about > >> three weeks to work on my cognitive process but it was so subtle I barely > >> thought it was the GXL. I wasn't having problems looking for words to > > finish > >> a sentence, my memory is back, I don't lose things around the house, I > > have > >> more energy and I feel good and my wife is happier. It is strange, when > >> I > >> asked my doctor about it he said Gluta what? it seems the medical > > community > >> is keeping the use of Glutathione (GSH) under wraps, they don't want > >> competition... I order mine from www.maxgxl.com/133282 I suggest > >> getting > >> as much info as possible of GSH, I went to www.youtube.com and searched > > for > >> 'The mother of all antioxidants', there is this doctor Mark Hyman who > >> explains in details about GSH; excellent video. > >> > >> Good luck to you. > >> > >> Ernesto, > >> Miami, FL > >> > >> On Sat, May 2, 2009 at 11:46 AM, john emrys <[log in to unmask]> > > wrote: > >> > >> > Hey John > >> > > >> > I've been on Amantadine since being diagnosed in October of last year; > >> > dosage has remained constant and titrated from 100mg to 300mg per day, > > over > >> > an initial period of 3 weeks. > >> > > >> > I space the dosing about 5-ish hours apart; I've found if the final > >> > dose > > of > >> > 100mg is taken later than 8PM, I have trouble sleeping through the > > night. > >> > > >> > It does give me an energy boost and some minor relief from muscle > >> > tightness, but does nothing to improve gait or reduce tremor. It's sort > > of > >> > just a little bit of "gas" for your "engine." > >> > > >> > On the other hand, I find it causes auditory hallucinations, > >> > drowsiness, > >> > occasional vertigo, foggy thought processing and swelling around the > > knees. > >> > > >> > I find much better results on GSH and mucuna bean, which I started > >> > about > > 6 > >> > months ago (the mucuna has been a very recent thing, so it's been too > > early > >> > to tell – but so far, I'm definitely impressed). My neuro practically > > lit > >> > his own hair on fire when I told him, but he couldn't deny the results > > of > >> > the GSH. > >> > > >> > The goal is to be able to cut the amantadine by 35 - 50% within 6 > > months. > >> > My view is the longer I stay away from starting the agonists, the > > better. > >> > > >> > Hope that helps. > >> > > >> > > >> > > >> > Joh > >> > > >> > > >> > ---------------------------------------------------------------------- > >> > To sign-off Parkinsn send a message to: mailto: > >> > [log in to unmask] > >> > In the body of the message put: signoff parkinsn > >> > > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn