thanks Roberta - I take bp medication Ray Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] -------------------------------------------------- From: <[log in to unmask]> Sent: Thursday, May 07, 2009 4:03 AM To: <[log in to unmask]> Subject: Re: Question re milk thistle > > > Doesn't Tyrosine increase blood pressure? > > Roberta Innarella > > > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, > [log in to unmask] writes: > > Yep! > > ----- Original Message ----- > From: "rayilynlee" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Tuesday, May 05, 2009 9:45 AM > Subject: Re: Question re milk thistle > > >> gee, I didn't know milk thistle would help my liver produce dopamine. >> I >> started taking it for constipation. Do I need to take tyrosine with it? >> >> Ray >> >> Rayilyn Brown >> Director AZNPF >> Arizona Chapter National Parkinson Foundation >> [log in to unmask] >> >> -------------------------------------------------- >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> >> Sent: Tuesday, May 05, 2009 8:40 AM >> To: <[log in to unmask]> >> Subject: Question re Amantadine/ GSH importance >> >> > Couple of thoughts. >> > Have you tried to let your liver produce your dopamine needs by taking >> > tyrosine and milk thistle? >> > The natural production of GSH by the body is a little more > complicated >> > but >> > following is article from my archives that helps explain. >> > WHY GSH >> > Oxidative stress appears to play an important role in degeneration of >> > dopaminergic neurons of the substantia nigra (SN) associated with >> > Parkinson's disease (PD). The SN of early PD patients have >> > dramatically >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH plays >> > multiple roles in the nervous system both as an antioxidant and a >> > redox >> > modulator. We have generated dopaminergic PC12 cell lines in which > levels >> > of >> > GSH can be inducibly down-regulated via doxycycline induction of > antisense >> > messages against both the heavy and light subunits of >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in >> > glutathione >> > synthesis. Down-regulation of glutamyl-cysteine synthetase results in >> > reduction in mitochondrial GSH levels, increased oxidative stress, and >> > decreased mitochondrial function. Interestingly, decreases in >> > mitochondrial >> > activities in GSH-depleted PC12 cells appears to be because of a > selective >> > inhibition of complex I activity as a result of thiol oxidation. These >> > results suggest that the early observed GSH losses in the SN may be >> > directly >> > responsible for the noted decreases in complex I activity and the >> > subsequent >> > mitochondrial dysfunction, which ultimately leads to dopaminergic >> cell >> > death >> > associated with PD. >> > >> > WHY GLUTAMINE >> > Glutamine is an important mitochondrial substrate implicated in the >> > protection of cells from oxidant injury. Human pulmonary > epithelial-like >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence and >> > presence >> > of glutamine. Cell proliferation in normoxia was dependent on > glutamine, >> > and >> > glutamine deprivation markedly accelerated cell death in hyperoxia. >> > Glutamine significantly increased cellular ATP levels in normoxia and >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived > cells. >> > Mitochondrial membrane potential as assessed by flow cytometry with >> > chloromethyltetramethylrosamine was increased by glutamine in >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent increase > in >> > mitochondrial membrane potential was detected. Glutamine-supplemented, >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and GSH >> > content. >> > Electron and fluorescence microscopy revealed that, in hyperoxia, >> > glutamine >> > protected cellular structures, especially mitochondria, from damage. >> > In >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme >> > alpha-ketoglutarate dehydrogenase was partially protected by its > indirect >> > substrate, glutamine, indicating a mechanism of mitochondrial > protection. >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of GSH >> > in >> > the >> > body naturally to further thwart the symptoms and destruction of P.D. >> > along >> > with my other vitamin/mineral protocol which exclude PD drugs. As a > note. >> > I >> > never tried the Amantadine. My doctors forced me early to look > elsewhere >> > for >> > help since they couldnt due to lack of knowledge or incentive. Not >> > sure >> > which but I'm alot healthier for switching to a no drug protocol. >> > >> > ----- Original Message ----- >> > From: "Ernesto Divo" <[log in to unmask]> >> > To: <[log in to unmask]> >> > Sent: Sunday, May 03, 2009 12:24 PM >> > Subject: Re: Question re Amantadine use >> > >> > >> >> Hi John, >> >> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect >> >> and >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. I have >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a >> > supplement >> >> developed here in the US, by a US scientist and sold by a US >> >> company. It raises thet levels of GSH in your cells naturally. It >> >> took >> >> the >> >> GXL about a week to work on my sleeping pattern, I was waking up 2-3 >> >> times >> >> during the night, now I sleep straight thru the night, and it took > about >> >> three weeks to work on my cognitive process but it was so subtle I > barely >> >> thought it was the GXL. I wasn't having problems looking for words to >> > finish >> >> a sentence, my memory is back, I don't lose things around the house, > I >> > have >> >> more energy and I feel good and my wife is happier. It is strange, > when >> >> I >> >> asked my doctor about it he said Gluta what? it seems the medical >> > community >> >> is keeping the use of Glutathione (GSH) under wraps, they don't want >> >> competition... I order mine from www.maxgxl.com/133282 I suggest >> >> getting >> >> as much info as possible of GSH, I went to www.youtube.com and > searched >> > for >> >> 'The mother of all antioxidants', there is this doctor Mark Hyman who >> >> explains in details about GSH; excellent video. >> >> >> >> Good luck to you. >> >> >> >> Ernesto, >> >> Miami, FL >> >> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys <[log in to unmask]> >> > wrote: >> >> >> >> > Hey John >> >> > >> >> > I've been on Amantadine since being diagnosed in October of last > year; >> >> > dosage has remained constant and titrated from 100mg to 300mg per > day, >> > over >> >> > an initial period of 3 weeks. >> >> > >> >> > I space the dosing about 5-ish hours apart; I've found if the final >> >> > dose >> > of >> >> > 100mg is taken later than 8PM, I have trouble sleeping through the >> > night. >> >> > >> >> > It does give me an energy boost and some minor relief from muscle >> >> > tightness, but does nothing to improve gait or reduce tremor. It's > sort >> > of >> >> > just a little bit of "gas" for your "engine." >> >> > >> >> > On the other hand, I find it causes auditory hallucinations, >> >> > drowsiness, >> >> > occasional vertigo, foggy thought processing and swelling around > the >> > knees. >> >> > >> >> > I find much better results on GSH and mucuna bean, which I started >> >> > about >> > 6 >> >> > months ago (the mucuna has been a very recent thing, so it's been > too >> > early >> >> > to tell – but so far, I'm definitely impressed). My neuro > practically >> > lit >> >> > his own hair on fire when I told him, but he couldn't deny the > results >> > of >> >> > the GSH. >> >> > >> >> > The goal is to be able to cut the amantadine by 35 - 50% within 6 >> > months. >> >> > My view is the longer I stay away from starting the agonists, the >> > better. >> >> > >> >> > Hope that helps. >> >> > >> >> > >> >> > >> >> > Joh >> >> > >> >> > >> >> >> ---------------------------------------------------------------------- >> >> > To sign-off Parkinsn send a message to: mailto: >> >> > [log in to unmask] >> >> > In the body of the message put: signoff parkinsn >> >> > >> >> >> >> >> > ---------------------------------------------------------------------- >> >> To sign-off Parkinsn send a message to: >> > mailto:[log in to unmask] >> >> In the body of the message put: signoff parkinsn >> > >> > ---------------------------------------------------------------------- >> > To sign-off Parkinsn send a message to: >> > mailto:[log in to unmask] >> > In the body of the message put: signoff parkinsn >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: > mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > oronto.ca > In the body of the message put: signoff parkinsn > > > > > **************Remember Mom this Mother's Day! 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