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To the best of my knowledge tyrosine has no impact on blood pressure. It is a precursor necessary for the production of dopamine by the liver. It is quite beneficial. Salt and sugar as well as poor diets have more impact on BP . Hope this helps. If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of walking I've been doing the last few days fixing storm damage on the ranch fences. Needless to say by sundown I'm really wornout for the day. Have a good Sunday Ray. ----- Original Message ----- From: "rayilynlee" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, May 08, 2009 10:48 AM Subject: Re: Question re milk thistle > thanks Roberta - I take bp medication > Ray > > Rayilyn Brown > Director AZNPF > Arizona Chapter National Parkinson Foundation > [log in to unmask] > > -------------------------------------------------- > From: <[log in to unmask]> > Sent: Thursday, May 07, 2009 4:03 AM > To: <[log in to unmask]> > Subject: Re: Question re milk thistle > > > > > > > Doesn't Tyrosine increase blood pressure? > > > > Roberta Innarella > > > > > > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, > > [log in to unmask] writes: > > > > Yep! > > > > ----- Original Message ----- > > From: "rayilynlee" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Tuesday, May 05, 2009 9:45 AM > > Subject: Re: Question re milk thistle > > > > > >> gee, I didn't know milk thistle would help my liver produce dopamine. > >> I > >> started taking it for constipation. Do I need to take tyrosine with it? > >> > >> Ray > >> > >> Rayilyn Brown > >> Director AZNPF > >> Arizona Chapter National Parkinson Foundation > >> [log in to unmask] > >> > >> -------------------------------------------------- > >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> > >> Sent: Tuesday, May 05, 2009 8:40 AM > >> To: <[log in to unmask]> > >> Subject: Question re Amantadine/ GSH importance > >> > >> > Couple of thoughts. > >> > Have you tried to let your liver produce your dopamine needs by taking > >> > tyrosine and milk thistle? > >> > The natural production of GSH by the body is a little more > > complicated > >> > but > >> > following is article from my archives that helps explain. > >> > WHY GSH > >> > Oxidative stress appears to play an important role in degeneration of > >> > dopaminergic neurons of the substantia nigra (SN) associated with > >> > Parkinson's disease (PD). The SN of early PD patients have > >> > dramatically > >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH plays > >> > multiple roles in the nervous system both as an antioxidant and a > >> > redox > >> > modulator. We have generated dopaminergic PC12 cell lines in which > > levels > >> > of > >> > GSH can be inducibly down-regulated via doxycycline induction of > > antisense > >> > messages against both the heavy and light subunits of > >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in > >> > glutathione > >> > synthesis. Down-regulation of glutamyl-cysteine synthetase results in > >> > reduction in mitochondrial GSH levels, increased oxidative stress, and > >> > decreased mitochondrial function. Interestingly, decreases in > >> > mitochondrial > >> > activities in GSH-depleted PC12 cells appears to be because of a > > selective > >> > inhibition of complex I activity as a result of thiol oxidation. These > >> > results suggest that the early observed GSH losses in the SN may be > >> > directly > >> > responsible for the noted decreases in complex I activity and the > >> > subsequent > >> > mitochondrial dysfunction, which ultimately leads to dopaminergic > >> cell > >> > death > >> > associated with PD. > >> > > >> > WHY GLUTAMINE > >> > Glutamine is an important mitochondrial substrate implicated in the > >> > protection of cells from oxidant injury. Human pulmonary > > epithelial-like > >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence and > >> > presence > >> > of glutamine. Cell proliferation in normoxia was dependent on > > glutamine, > >> > and > >> > glutamine deprivation markedly accelerated cell death in hyperoxia. > >> > Glutamine significantly increased cellular ATP levels in normoxia and > >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived > > cells. > >> > Mitochondrial membrane potential as assessed by flow cytometry with > >> > chloromethyltetramethylrosamine was increased by glutamine in > >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent increase > > in > >> > mitochondrial membrane potential was detected. Glutamine-supplemented, > >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and GSH > >> > content. > >> > Electron and fluorescence microscopy revealed that, in hyperoxia, > >> > glutamine > >> > protected cellular structures, especially mitochondria, from damage. > >> > In > >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme > >> > alpha-ketoglutarate dehydrogenase was partially protected by its > > indirect > >> > substrate, glutamine, indicating a mechanism of mitochondrial > > protection. > >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of GSH > >> > in > >> > the > >> > body naturally to further thwart the symptoms and destruction of P.D. > >> > along > >> > with my other vitamin/mineral protocol which exclude PD drugs. As a > > note. > >> > I > >> > never tried the Amantadine. My doctors forced me early to look > > elsewhere > >> > for > >> > help since they couldnt due to lack of knowledge or incentive. Not > >> > sure > >> > which but I'm alot healthier for switching to a no drug protocol. > >> > > >> > ----- Original Message ----- > >> > From: "Ernesto Divo" <[log in to unmask]> > >> > To: <[log in to unmask]> > >> > Sent: Sunday, May 03, 2009 12:24 PM > >> > Subject: Re: Question re Amantadine use > >> > > >> > > >> >> Hi John, > >> >> > >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect > >> >> and > >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. I have > >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a > >> > supplement > >> >> developed here in the US, by a US scientist and sold by a US > >> >> company. It raises thet levels of GSH in your cells naturally. It > >> >> took > >> >> the > >> >> GXL about a week to work on my sleeping pattern, I was waking up 2-3 > >> >> times > >> >> during the night, now I sleep straight thru the night, and it took > > about > >> >> three weeks to work on my cognitive process but it was so subtle I > > barely > >> >> thought it was the GXL. I wasn't having problems looking for words to > >> > finish > >> >> a sentence, my memory is back, I don't lose things around the house, > > I > >> > have > >> >> more energy and I feel good and my wife is happier. It is strange, > > when > >> >> I > >> >> asked my doctor about it he said Gluta what? it seems the medical > >> > community > >> >> is keeping the use of Glutathione (GSH) under wraps, they don't want > >> >> competition... I order mine from www.maxgxl.com/133282 I suggest > >> >> getting > >> >> as much info as possible of GSH, I went to www.youtube.com and > > searched > >> > for > >> >> 'The mother of all antioxidants', there is this doctor Mark Hyman who > >> >> explains in details about GSH; excellent video. > >> >> > >> >> Good luck to you. > >> >> > >> >> Ernesto, > >> >> Miami, FL > >> >> > >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys <[log in to unmask]> > >> > wrote: > >> >> > >> >> > Hey John > >> >> > > >> >> > I've been on Amantadine since being diagnosed in October of last > > year; > >> >> > dosage has remained constant and titrated from 100mg to 300mg per > > day, > >> > over > >> >> > an initial period of 3 weeks. > >> >> > > >> >> > I space the dosing about 5-ish hours apart; I've found if the final > >> >> > dose > >> > of > >> >> > 100mg is taken later than 8PM, I have trouble sleeping through the > >> > night. > >> >> > > >> >> > It does give me an energy boost and some minor relief from muscle > >> >> > tightness, but does nothing to improve gait or reduce tremor. It's > > sort > >> > of > >> >> > just a little bit of "gas" for your "engine." > >> >> > > >> >> > On the other hand, I find it causes auditory hallucinations, > >> >> > drowsiness, > >> >> > occasional vertigo, foggy thought processing and swelling around > > the > >> > knees. > >> >> > > >> >> > I find much better results on GSH and mucuna bean, which I started > >> >> > about > >> > 6 > >> >> > months ago (the mucuna has been a very recent thing, so it's been > > too > >> > early > >> >> > to tell – but so far, I'm definitely impressed). My neuro > > practically > >> > lit > >> >> > his own hair on fire when I told him, but he couldn't deny the > > results > >> > of > >> >> > the GSH. > >> >> > > >> >> > The goal is to be able to cut the amantadine by 35 - 50% within 6 > >> > months. > >> >> > My view is the longer I stay away from starting the agonists, the > >> > better. > >> >> > > >> >> > Hope that helps. > >> >> > > >> >> > > >> >> > > >> >> > Joh > >> >> > > >> >> > > >> >> > >> ---------------------------------------------------------------------- > >> >> > To sign-off Parkinsn send a message to: mailto: > >> >> > [log in to unmask] > >> >> > In the body of the message put: signoff parkinsn > >> >> > > >> >> > >> > >> >> > ---------------------------------------------------------------------- > >> >> To sign-off Parkinsn send a message to: > >> > mailto:[log in to unmask] > >> >> In the body of the message put: signoff parkinsn > >> > > >> ---------------------------------------------------------------------- > >> > To sign-off Parkinsn send a message to: > >> > mailto:[log in to unmask] > >> > In the body of the message put: signoff parkinsn > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > > oronto.ca > > In the body of the message put: signoff parkinsn > > > > > > > > > > **************Remember Mom this Mother's Day! Find a florist near you now. > > (http://yellowpages.aol.com/search?query=florist&ncid=emlcntusyelp00000006) > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn