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Rob I got the 250 milk thistle. It seems to me that taking small doses several times a day is the way to go. Why didn't I think of that?? The tyrosine should arrive soon. I'll order some Bs and try your regime. Thank you so much. Ray Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] -------------------------------------------------- From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> Sent: Tuesday, May 12, 2009 12:27 PM To: <[log in to unmask]> Subject: Re: Question re milk thistleand tyrosine > I also do not take any PD meds. I take painkillers periodically from > trying > to stay to active with PD and a lot of other antioxidants, minerals, and > vits. > > Personally I take 200mg of similar milk thistle three times a day and > 500mg > of L-tyrosine three times a day. I take low doses multiple times a day to > aid in maintaining blood levels . I use small bottles and sort my > vitamins > and minerals out once a month to am, noon's, and pms. This keeps me on > track > for taking them better than any other system I've tried. > The doses you ordered may just work fine to jump start you "off the couch" > so to speak. Milk thistle is good for the liver so I cant see the large > dose > being of any concern. Most of my "drinking" friends finally have started > taking milk thistle before they go out to avoid the " hangover" so they > can > drink more and party more, I guess. I dont understand that scene but it > really does help with the aftereffects. > It has been known for years to cure cerosis of the liver and lately it has > been found very helpful in stopping mastastisis of breast cancer. So with > your past history it may long be overdue. I hope it helps you and dont > forget to take a few B vitamins along the way too. > Your friend , Rob > > ----- Original Message ----- > From: "rayilynlee" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Sunday, May 10, 2009 1:26 AM > Subject: Re: Question re milk thistleand tyrosine > > >> Schaff: >> >> I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the > correct >> amount or not? >> thanks so much and for clarifying the bp issue. I couldn't find >> anything >> on line that said tyrosine caused high bp - and yes it did claim these 2 >> supplements as treatment for PD. thanks so very much >> >> here's hoping....I don't take PD meds you know, but am getting worse >> >> Ray >> >> Rayilyn Brown >> Director AZNPF >> Arizona Chapter National Parkinson Foundation >> [log in to unmask] >> >> -------------------------------------------------- >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> >> Sent: Sunday, May 10, 2009 8:09 PM >> To: <[log in to unmask]> >> Subject: Re: Question re milk thistleand tyrosine >> >> > To the best of my knowledge tyrosine has no impact on blood pressure. >> > It >> > is >> > a precursor necessary for the production of dopamine by the liver. It >> > is >> > quite beneficial. Salt and sugar as well as poor diets have more impact > on >> > BP . >> > Hope this helps. >> > If it werent for tyrosine in my program I couldnt do the 5 to 6 hours >> > of >> > walking I've been doing the last few days fixing storm damage on the > ranch >> > fences. Needless to say by sundown I'm really wornout for the day. >> > Have a good Sunday Ray. >> > >> > ----- Original Message ----- >> > From: "rayilynlee" <[log in to unmask]> >> > To: <[log in to unmask]> >> > Sent: Friday, May 08, 2009 10:48 AM >> > Subject: Re: Question re milk thistle >> > >> > >> >> thanks Roberta - I take bp medication >> >> Ray >> >> >> >> Rayilyn Brown >> >> Director AZNPF >> >> Arizona Chapter National Parkinson Foundation >> >> [log in to unmask] >> >> >> >> -------------------------------------------------- >> >> From: <[log in to unmask]> >> >> Sent: Thursday, May 07, 2009 4:03 AM >> >> To: <[log in to unmask]> >> >> Subject: Re: Question re milk thistle >> >> >> >> > >> >> > >> >> > Doesn't Tyrosine increase blood pressure? >> >> > >> >> > Roberta Innarella >> >> > >> >> > >> >> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, >> >> > [log in to unmask] writes: >> >> > >> >> > Yep! >> >> > >> >> > ----- Original Message ----- >> >> > From: "rayilynlee" <[log in to unmask]> >> >> > To: <[log in to unmask]> >> >> > Sent: Tuesday, May 05, 2009 9:45 AM >> >> > Subject: Re: Question re milk thistle >> >> > >> >> > >> >> >> gee, I didn't know milk thistle would help my liver produce > dopamine. >> >> >> I >> >> >> started taking it for constipation. Do I need to take tyrosine > with >> > it? >> >> >> >> >> >> Ray >> >> >> >> >> >> Rayilyn Brown >> >> >> Director AZNPF >> >> >> Arizona Chapter National Parkinson Foundation >> >> >> [log in to unmask] >> >> >> >> >> >> -------------------------------------------------- >> >> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> >> >> >> Sent: Tuesday, May 05, 2009 8:40 AM >> >> >> To: <[log in to unmask]> >> >> >> Subject: Question re Amantadine/ GSH importance >> >> >> >> >> >> > Couple of thoughts. >> >> >> > Have you tried to let your liver produce your dopamine needs by >> > taking >> >> >> > tyrosine and milk thistle? >> >> >> > The natural production of GSH by the body is a little more >> >> > complicated >> >> >> > but >> >> >> > following is article from my archives that helps explain. >> >> >> > WHY GSH >> >> >> > Oxidative stress appears to play an important role in > degeneration >> > of >> >> >> > dopaminergic neurons of the substantia nigra (SN) associated >> >> >> > with >> >> >> > Parkinson's disease (PD). The SN of early PD patients have >> >> >> > dramatically >> >> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH >> > plays >> >> >> > multiple roles in the nervous system both as an antioxidant and >> >> >> > a >> >> >> > redox >> >> >> > modulator. We have generated dopaminergic PC12 cell lines in > which >> >> > levels >> >> >> > of >> >> >> > GSH can be inducibly down-regulated via doxycycline induction of >> >> > antisense >> >> >> > messages against both the heavy and light subunits of >> >> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in >> >> >> > glutathione >> >> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase > results >> > in >> >> >> > reduction in mitochondrial GSH levels, increased oxidative > stress, >> > and >> >> >> > decreased mitochondrial function. Interestingly, decreases in >> >> >> > mitochondrial >> >> >> > activities in GSH-depleted PC12 cells appears to be because of a >> >> > selective >> >> >> > inhibition of complex I activity as a result of thiol oxidation. >> > These >> >> >> > results suggest that the early observed GSH losses in the SN may >> >> >> > be >> >> >> > directly >> >> >> > responsible for the noted decreases in complex I activity and >> >> >> > the >> >> >> > subsequent >> >> >> > mitochondrial dysfunction, which ultimately leads to >> >> >> dopaminergic >> >> >> cell >> >> >> > death >> >> >> > associated with PD. >> >> >> > >> >> >> > WHY GLUTAMINE >> >> >> > Glutamine is an important mitochondrial substrate implicated in > the >> >> >> > protection of cells from oxidant injury. Human pulmonary >> >> > epithelial-like >> >> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence > and >> >> >> > presence >> >> >> > of glutamine. Cell proliferation in normoxia was dependent on >> >> > glutamine, >> >> >> > and >> >> >> > glutamine deprivation markedly accelerated cell death in > hyperoxia. >> >> >> > Glutamine significantly increased cellular ATP levels in >> >> >> > normoxia >> > and >> >> >> > prevented the loss of ATP in hyperoxia seen in >> >> >> > glutamine-deprived >> >> > cells. >> >> >> > Mitochondrial membrane potential as assessed by flow cytometry > with >> >> >> > chloromethyltetramethylrosamine was increased by glutamine in >> >> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent >> > increase >> >> > in >> >> >> > mitochondrial membrane potential was detected. >> > Glutamine-supplemented, >> >> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and > GSH >> >> >> > content. >> >> >> > Electron and fluorescence microscopy revealed that, in > hyperoxia, >> >> >> > glutamine >> >> >> > protected cellular structures, especially mitochondria, from >> >> >> > damage. >> >> >> > In >> >> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme >> >> >> > alpha-ketoglutarate dehydrogenase was partially protected by >> >> >> > its >> >> > indirect >> >> >> > substrate, glutamine, indicating a mechanism of mitochondrial >> >> > protection. >> >> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of >> >> >> > GSH >> >> >> > in >> >> >> > the >> >> >> > body naturally to further thwart the symptoms and destruction of >> > P.D. >> >> >> > along >> >> >> > with my other vitamin/mineral protocol which exclude PD drugs. >> >> >> > As > a >> >> > note. >> >> >> > I >> >> >> > never tried the Amantadine. My doctors forced me early to look >> >> > elsewhere >> >> >> > for >> >> >> > help since they couldnt due to lack of knowledge or incentive. > Not >> >> >> > sure >> >> >> > which but I'm alot healthier for switching to a no drug > protocol. >> >> >> > >> >> >> > ----- Original Message ----- >> >> >> > From: "Ernesto Divo" <[log in to unmask]> >> >> >> > To: <[log in to unmask]> >> >> >> > Sent: Sunday, May 03, 2009 12:24 PM >> >> >> > Subject: Re: Question re Amantadine use >> >> >> > >> >> >> > >> >> >> >> Hi John, >> >> >> >> >> >> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking > Azilect >> >> >> >> and >> >> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. >> >> >> >> I >> > have >> >> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', > a >> >> >> > supplement >> >> >> >> developed here in the US, by a US scientist and sold by a US >> >> >> >> company. It raises thet levels of GSH in your cells naturally. > It >> >> >> >> took >> >> >> >> the >> >> >> >> GXL about a week to work on my sleeping pattern, I was waking >> >> >> >> up >> > 2-3 >> >> >> >> times >> >> >> >> during the night, now I sleep straight thru the night, and it > took >> >> > about >> >> >> >> three weeks to work on my cognitive process but it was so >> >> >> >> subtle >> >> >> >> I >> >> > barely >> >> >> >> thought it was the GXL. I wasn't having problems looking for > words >> > to >> >> >> > finish >> >> >> >> a sentence, my memory is back, I don't lose things around the >> > house, >> >> > I >> >> >> > have >> >> >> >> more energy and I feel good and my wife is happier. It is >> >> >> >> strange, >> >> > when >> >> >> >> I >> >> >> >> asked my doctor about it he said Gluta what? it seems the >> >> >> medical >> >> >> > community >> >> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't >> > want >> >> >> >> competition... I order mine from www.maxgxl.com/133282 I >> >> >> >> suggest >> >> >> >> getting >> >> >> >> as much info as possible of GSH, I went to www.youtube.com and >> >> > searched >> >> >> > for >> >> >> >> 'The mother of all antioxidants', there is this doctor Mark > Hyman >> > who >> >> >> >> explains in details about GSH; excellent video. >> >> >> >> >> >> >> >> Good luck to you. >> >> >> >> >> >> >> >> Ernesto, >> >> >> >> Miami, FL >> >> >> >> >> >> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys >> > <[log in to unmask]> >> >> >> > wrote: >> >> >> >> >> >> >> >> > Hey John >> >> >> >> > >> >> >> >> > I've been on Amantadine since being diagnosed in October of >> >> >> last >> >> > year; >> >> >> >> > dosage has remained constant and titrated from 100mg to 300mg >> >> >> >> > per >> >> > day, >> >> >> > over >> >> >> >> > an initial period of 3 weeks. >> >> >> >> > >> >> >> >> > I space the dosing about 5-ish hours apart; I've found if the >> > final >> >> >> >> > dose >> >> >> > of >> >> >> >> > 100mg is taken later than 8PM, I have trouble sleeping >> >> >> >> > through >> > the >> >> >> > night. >> >> >> >> > >> >> >> >> > It does give me an energy boost and some minor relief from >> > muscle >> >> >> >> > tightness, but does nothing to improve gait or reduce tremor. >> > It's >> >> > sort >> >> >> > of >> >> >> >> > just a little bit of "gas" for your "engine." >> >> >> >> > >> >> >> >> > On the other hand, I find it causes auditory hallucinations, >> >> >> >> > drowsiness, >> >> >> >> > occasional vertigo, foggy thought processing and swelling > around >> >> > the >> >> >> > knees. >> >> >> >> > >> >> >> >> > I find much better results on GSH and mucuna bean, which I >> > started >> >> >> >> > about >> >> >> > 6 >> >> >> >> > months ago (the mucuna has been a very recent thing, so it's >> >> >> >> > been >> >> > too >> >> >> > early >> >> >> >> > to tell – but so far, I'm definitely impressed). My neuro >> >> > practically >> >> >> > lit >> >> >> >> > his own hair on fire when I told him, but he couldn't deny > the >> >> > results >> >> >> > of >> >> >> >> > the GSH. >> >> >> >> > >> >> >> >> > The goal is to be able to cut the amantadine by 35 - 50% > within >> >> >> >> > 6 >> >> >> > months. >> >> >> >> > My view is the longer I stay away from starting the agonists, >> > the >> >> >> > better. >> >> >> >> > >> >> >> >> > Hope that helps. >> >> >> >> > >> >> >> >> > >> >> >> >> > >> >> >> >> > Joh >> >> >> >> > >> >> >> >> > >> >> >> >> >> >> >> >> >> >> ---------------------------------------------------------------------- >> >> >> >> > To sign-off Parkinsn send a message to: mailto: >> >> >> >> > [log in to unmask] >> >> >> >> > In the body of the message put: signoff parkinsn >> >> >> >> > >> >> >> >> >> >> >> >> >> >> >> >> >> >> > ---------------------------------------------------------------------- >> >> >> >> To sign-off Parkinsn send a message to: >> >> >> > mailto:[log in to unmask] >> >> >> >> In the body of the message put: signoff parkinsn >> >> >> > >> >> >> >> > ---------------------------------------------------------------------- >> >> >> > To sign-off Parkinsn send a message to: >> >> >> > mailto:[log in to unmask] >> >> >> > In the body of the message put: signoff parkinsn >> >> >> >> >> >> >> >> >> ---------------------------------------------------------------------- >> >> >> To sign-off Parkinsn send a message to: >> >> > mailto:[log in to unmask] >> >> >> In the body of the message put: signoff parkinsn >> >> > >> >> >> ---------------------------------------------------------------------- >> >> > To sign-off Parkinsn send a message to: >> >> > mailto:[log in to unmask] >> >> > oronto.ca >> >> > In the body of the message put: signoff parkinsn >> >> > >> >> > >> >> > >> >> > >> >> > **************Remember Mom this Mother's Day! 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