 |
 |
Roberta I don't take any MAO inhibitors or much else so the tyrosine is most likely OK for me. thanks for clarifying the issue. It would be great if I could lose some fat. Ray Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] -------------------------------------------------- From: <[log in to unmask]> Sent: Sunday, May 10, 2009 8:23 AM To: <[log in to unmask]> Subject: Re: Question re milk thistleand tyrosine > > > The following taken from "Prescription for Nutritional Healing" Third > Edition: > > "Tyrosine is important to overall metabolism. It is a precursor of > adrenaline and the neurotransmiters norepinephrine and dopamine, which > regulate > mood and stimulate metabolism and the nervous system. Tyrosine acts as a > mood elevator; a lack of adequate amounts of tyrosine leads to a > deficiency > of norepinephrine in the brain, which in turn can result in depression. > It > also acts as a mild antioxidant, suppresses the appetite, and helps to > reduce body fat. It aids in the production of melanin (the pigment > responsible > for skin and hair color) and in the functions of the adrenal, thyroid, > and > pituitary glands. It is also involved in the metabolism of the amino > acid > phenylalanine. > > Tyrosine attaches to iodine atoms to form active thyroid hormones. Not > surprisingly, therefore, low plasma levels of tyrosine have been > associated > with hypothyroidism. Symptoms of tyrosine deficiency can also include > low > blood pressure, low body temperature (such as cold hands and feet), and > restless leg syndrome. > > Supplemental L-tyrosine has been used for stress reduction, and research > suggests it may be helpful against chronic fatigue and narcolepsy. It > has > been used to help individuals suffering from anxiety, depression, low sex > drive, allergies, and headaches, as well as persons undergoing withdrawal > from drugs. It may also help people with Parkinson's disease. > > Natural resources of tyrosine include almonds, avocados, bananas, dairy > products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine can also > be > produced from phenylalanine in the body. Supplements of L-tyrosine > should > be taken at bedtime or with a high-carbohydrate meal so that it does not > have to complete for absorption with other amino acids. > > Persons taking monoamine oxidase (MAO)) inhibitors, commonly prescribed > for depression, must strictly limit their intake of foods containing > tyrosine > and should not take any supplements containing L-tyrosine, as it may lead > to a sudden and dangerous rise in blood pressure. Anyone who takes > prescription medication for depression should discuss necessary dietary > restrictions with his or her physician." > > I take Azilect which is an MOA (B) not (A) inhibitor so I don't know if > the last paragraph would apply as I obviously don't take it for > depression > but for PD. I guess I'll need to research further unless anyone on this > forum knows the answer. > > Roberta Innarella > > > In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time, > [log in to unmask] writes: > > Schaff: > > I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the > correct > amount or not? > thanks so much and for clarifying the bp issue. I couldn't find > anything > > on line that said tyrosine caused high bp - and yes it did claim these 2 > supplements as treatment for PD. thanks so very much > > here's hoping....I don't take PD meds you know, but am getting worse > > Ray > > Rayilyn Brown > Director AZNPF > Arizona Chapter National Parkinson Foundation > [log in to unmask] > > -------------------------------------------------- > From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> > Sent: Sunday, May 10, 2009 8:09 PM > To: <[log in to unmask]> > Subject: Re: Question re milk thistleand tyrosine > >> To the best of my knowledge tyrosine has no impact on blood pressure. It >> is >> a precursor necessary for the production of dopamine by the liver. It is >> quite beneficial. Salt and sugar as well as poor diets have more impact > on >> BP . >> Hope this helps. >> If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of >> walking I've been doing the last few days fixing storm damage on the > ranch >> fences. Needless to say by sundown I'm really wornout for the day. >> Have a good Sunday Ray. >> >> ----- Original Message ----- >> From: "rayilynlee" <[log in to unmask]> >> To: <[log in to unmask]> >> Sent: Friday, May 08, 2009 10:48 AM >> Subject: Re: Question re milk thistle >> >> >>> thanks Roberta - I take bp medication >>> Ray >>> >>> Rayilyn Brown >>> Director AZNPF >>> Arizona Chapter National Parkinson Foundation >>> [log in to unmask] >>> >>> -------------------------------------------------- >>> From: <[log in to unmask]> >>> Sent: Thursday, May 07, 2009 4:03 AM >>> To: <[log in to unmask]> >>> Subject: Re: Question re milk thistle >>> >>> > >>> > >>> > Doesn't Tyrosine increase blood pressure? >>> > >>> > Roberta Innarella >>> > >>> > >>> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, >>> > [log in to unmask] writes: >>> > >>> > Yep! >>> > >>> > ----- Original Message ----- >>> > From: "rayilynlee" <[log in to unmask]> >>> > To: <[log in to unmask]> >>> > Sent: Tuesday, May 05, 2009 9:45 AM >>> > Subject: Re: Question re milk thistle >>> > >>> > >>> >> gee, I didn't know milk thistle would help my liver produce > dopamine. >>> >> I >>> >> started taking it for constipation. Do I need to take tyrosine >>> >> with >> it? >>> >> >>> >> Ray >>> >> >>> >> Rayilyn Brown >>> >> Director AZNPF >>> >> Arizona Chapter National Parkinson Foundation >>> >> [log in to unmask] >>> >> >>> >> -------------------------------------------------- >>> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> >>> >> Sent: Tuesday, May 05, 2009 8:40 AM >>> >> To: <[log in to unmask]> >>> >> Subject: Question re Amantadine/ GSH importance >>> >> >>> >> > Couple of thoughts. >>> >> > Have you tried to let your liver produce your dopamine needs by >> taking >>> >> > tyrosine and milk thistle? >>> >> > The natural production of GSH by the body is a little more >>> > complicated >>> >> > but >>> >> > following is article from my archives that helps explain. >>> >> > WHY GSH >>> >> > Oxidative stress appears to play an important role in >>> >> > degeneration >> of >>> >> > dopaminergic neurons of the substantia nigra (SN) associated >>> >> with >>> >> > Parkinson's disease (PD). The SN of early PD patients have >>> >> > dramatically >>> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH >> plays >>> >> > multiple roles in the nervous system both as an antioxidant and >>> a >>> >> > redox >>> >> > modulator. We have generated dopaminergic PC12 cell lines in > which >>> > levels >>> >> > of >>> >> > GSH can be inducibly down-regulated via doxycycline induction of >>> > antisense >>> >> > messages against both the heavy and light subunits of >>> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in >>> >> > glutathione >>> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase >>> >> > results >> in >>> >> > reduction in mitochondrial GSH levels, increased oxidative > stress, >> and >>> >> > decreased mitochondrial function. Interestingly, decreases in >>> >> > mitochondrial >>> >> > activities in GSH-depleted PC12 cells appears to be because of a >>> > selective >>> >> > inhibition of complex I activity as a result of thiol oxidation. >> These >>> >> > results suggest that the early observed GSH losses in the SN may >>> >> > be >>> >> > directly >>> >> > responsible for the noted decreases in complex I activity and the >>> >> > subsequent >>> >> > mitochondrial dysfunction, which ultimately leads to dopaminergic >>> >> cell >>> >> > death >>> >> > associated with PD. >>> >> > >>> >> > WHY GLUTAMINE >>> >> > Glutamine is an important mitochondrial substrate implicated in > the >>> >> > protection of cells from oxidant injury. Human pulmonary >>> > epithelial-like >>> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence > and >>> >> > presence >>> >> > of glutamine. Cell proliferation in normoxia was dependent on >>> > glutamine, >>> >> > and >>> >> > glutamine deprivation markedly accelerated cell death in > hyperoxia. >>> >> > Glutamine significantly increased cellular ATP levels in normoxia >> and >>> >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived >>> > cells. >>> >> > Mitochondrial membrane potential as assessed by flow cytometry > with >>> >> > chloromethyltetramethylrosamine was increased by glutamine in >>> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent >> increase >>> > in >>> >> > mitochondrial membrane potential was detected. >> Glutamine-supplemented, >>> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and > GSH >>> >> > content. >>> >> > Electron and fluorescence microscopy revealed that, in > hyperoxia, >>> >> > glutamine >>> >> > protected cellular structures, especially mitochondria, from >>> >> > damage. >>> >> > In >>> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme >>> >> > alpha-ketoglutarate dehydrogenase was partially protected by >>> >> > its >>> > indirect >>> >> > substrate, glutamine, indicating a mechanism of mitochondrial >>> > protection. >>> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of >>> >> > GSH >>> >> > in >>> >> > the >>> >> > body naturally to further thwart the symptoms and destruction of >> P.D. >>> >> > along >>> >> > with my other vitamin/mineral protocol which exclude PD drugs. As > a >>> > note. >>> >> > I >>> >> > never tried the Amantadine. My doctors forced me early to look >>> > elsewhere >>> >> > for >>> >> > help since they couldnt due to lack of knowledge or incentive. > Not >>> >> > sure >>> >> > which but I'm alot healthier for switching to a no drug > protocol. >>> >> > >>> >> > ----- Original Message ----- >>> >> > From: "Ernesto Divo" <[log in to unmask]> >>> >> > To: <[log in to unmask]> >>> >> > Sent: Sunday, May 03, 2009 12:24 PM >>> >> > Subject: Re: Question re Amantadine use >>> >> > >>> >> > >>> >> >> Hi John, >>> >> >> >>> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking > Azilect >>> >> >> and >>> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. >>> >> >> I >> have >>> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', > a >>> >> > supplement >>> >> >> developed here in the US, by a US scientist and sold by a US >>> >> >> company. It raises thet levels of GSH in your cells naturally. >>> >> >> It >>> >> >> took >>> >> >> the >>> >> >> GXL about a week to work on my sleeping pattern, I was waking >>> >> up >> 2-3 >>> >> >> times >>> >> >> during the night, now I sleep straight thru the night, and it > took >>> > about >>> >> >> three weeks to work on my cognitive process but it was so > subtle >>> >> >> I >>> > barely >>> >> >> thought it was the GXL. I wasn't having problems looking for > words >> to >>> >> > finish >>> >> >> a sentence, my memory is back, I don't lose things around the >> house, >>> > I >>> >> > have >>> >> >> more energy and I feel good and my wife is happier. It is >>> >> >> strange, >>> > when >>> >> >> I >>> >> >> asked my doctor about it he said Gluta what? it seems the >>> >> medical >>> >> > community >>> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't >> want >>> >> >> competition... I order mine from www.maxgxl.com/133282 I >>> >> >> suggest >>> >> >> getting >>> >> >> as much info as possible of GSH, I went to www.youtube.com and >>> > searched >>> >> > for >>> >> >> 'The mother of all antioxidants', there is this doctor Mark >>> >> >> Hyman >> who >>> >> >> explains in details about GSH; excellent video. >>> >> >> >>> >> >> Good luck to you. >>> >> >> >>> >> >> Ernesto, >>> >> >> Miami, FL >>> >> >> >>> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys >> <[log in to unmask]> >>> >> > wrote: >>> >> >> >>> >> >> > Hey John >>> >> >> > >>> >> >> > I've been on Amantadine since being diagnosed in October of >>> >> last >>> > year; >>> >> >> > dosage has remained constant and titrated from 100mg to 300mg >>> >> >> > per >>> > day, >>> >> > over >>> >> >> > an initial period of 3 weeks. >>> >> >> > >>> >> >> > I space the dosing about 5-ish hours apart; I've found if the >> final >>> >> >> > dose >>> >> > of >>> >> >> > 100mg is taken later than 8PM, I have trouble sleeping >>> >> >> through >> the >>> >> > night. >>> >> >> > >>> >> >> > It does give me an energy boost and some minor relief from >> muscle >>> >> >> > tightness, but does nothing to improve gait or reduce tremor. >> It's >>> > sort >>> >> > of >>> >> >> > just a little bit of "gas" for your "engine." >>> >> >> > >>> >> >> > On the other hand, I find it causes auditory hallucinations, >>> >> >> > drowsiness, >>> >> >> > occasional vertigo, foggy thought processing and swelling > around >>> > the >>> >> > knees. >>> >> >> > >>> >> >> > I find much better results on GSH and mucuna bean, which I >> started >>> >> >> > about >>> >> > 6 >>> >> >> > months ago (the mucuna has been a very recent thing, so it's >>> >> >> > been >>> > too >>> >> > early >>> >> >> > to tell – but so far, I'm definitely impressed). My neuro >>> > practically >>> >> > lit >>> >> >> > his own hair on fire when I told him, but he couldn't deny > the >>> > results >>> >> > of >>> >> >> > the GSH. >>> >> >> > >>> >> >> > The goal is to be able to cut the amantadine by 35 - 50% > within >>> >> >> > 6 >>> >> > months. >>> >> >> > My view is the longer I stay away from starting the agonists, >> the >>> >> > better. >>> >> >> > >>> >> >> > Hope that helps. >>> >> >> > >>> >> >> > >>> >> >> > >>> >> >> > Joh >>> >> >> > >>> >> >> > >>> >> >> >>> >>> >> > > ---------------------------------------------------------------------- >>> >> >> > To sign-off Parkinsn send a message to: mailto: >>> >> >> > [log in to unmask] >>> >> >> > In the body of the message put: signoff parkinsn >>> >> >> > >>> >> >> >>> >> >>> >> >> >>> ---------------------------------------------------------------------- >>> >> >> To sign-off Parkinsn send a message to: >>> >> > mailto:[log in to unmask] >>> >> >> In the body of the message put: signoff parkinsn >>> >> > >>> >> >> ---------------------------------------------------------------------- >>> >> > To sign-off Parkinsn send a message to: >>> >> > mailto:[log in to unmask] >>> >> > In the body of the message put: signoff parkinsn >>> >> >>> >>> >> > > ---------------------------------------------------------------------- >>> >> To sign-off Parkinsn send a message to: >>> > mailto:[log in to unmask] >>> >> In the body of the message put: signoff parkinsn >>> &> >>> >>> > ---------------------------------------------------------------------- >>> > To sign-off Parkinsn send a message to: >>> mailto:[log in to unmask] >>> > oronto.ca >>> > In the body of the message put: signoff parkinsn >>> > >>> > >>> > >>> > >>> > **************Remember Mom this Mother's Day! Find a florist near >>> > you >> now. >>> > >> > (http://yellowpages.aol.com/search?query=florist&ncid=emlcntusyelp00000006) >>> > >>> >>> > ---------------------------------------------------------------------- >>> > To sign-off Parkinsn send a message to: >>> > mailto:[log in to unmask] >>> > In the body of the message put: signoff parkinsn >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >>> In the body of the message put: signoff parkinsn >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > > > > **************Recession-proof vacation ideas. Find free things to do in > the U.S. > (http://travel.aol.com/travel-ideas/domestic/national-tourism-week?ncid=emlcntustrav00000002) > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn