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The following taken from "Prescription for Nutritional Healing" Third Edition: "Tyrosine is important to overall metabolism. It is a precursor of adrenaline and the neurotransmiters norepinephrine and dopamine, which regulate mood and stimulate metabolism and the nervous system. Tyrosine acts as a mood elevator; a lack of adequate amounts of tyrosine leads to a deficiency of norepinephrine in the brain, which in turn can result in depression. It also acts as a mild antioxidant, suppresses the appetite, and helps to reduce body fat. It aids in the production of melanin (the pigment responsible for skin and hair color) and in the functions of the adrenal, thyroid, and pituitary glands. It is also involved in the metabolism of the amino acid phenylalanine. Tyrosine attaches to iodine atoms to form active thyroid hormones. Not surprisingly, therefore, low plasma levels of tyrosine have been associated with hypothyroidism. Symptoms of tyrosine deficiency can also include low blood pressure, low body temperature (such as cold hands and feet), and restless leg syndrome. Supplemental L-tyrosine has been used for stress reduction, and research suggests it may be helpful against chronic fatigue and narcolepsy. It has been used to help individuals suffering from anxiety, depression, low sex drive, allergies, and headaches, as well as persons undergoing withdrawal from drugs. It may also help people with Parkinson's disease. Natural resources of tyrosine include almonds, avocados, bananas, dairy products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine can also be produced from phenylalanine in the body. Supplements of L-tyrosine should be taken at bedtime or with a high-carbohydrate meal so that it does not have to complete for absorption with other amino acids. Persons taking monoamine oxidase (MAO)) inhibitors, commonly prescribed for depression, must strictly limit their intake of foods containing tyrosine and should not take any supplements containing L-tyrosine, as it may lead to a sudden and dangerous rise in blood pressure. Anyone who takes prescription medication for depression should discuss necessary dietary restrictions with his or her physician." I take Azilect which is an MOA (B) not (A) inhibitor so I don't know if the last paragraph would apply as I obviously don't take it for depression but for PD. I guess I'll need to research further unless anyone on this forum knows the answer. Roberta Innarella In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time, [log in to unmask] writes: Schaff: I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the correct amount or not? thanks so much and for clarifying the bp issue. I couldn't find anything on line that said tyrosine caused high bp - and yes it did claim these 2 supplements as treatment for PD. thanks so very much here's hoping....I don't take PD meds you know, but am getting worse Ray Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] -------------------------------------------------- From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> Sent: Sunday, May 10, 2009 8:09 PM To: <[log in to unmask]> Subject: Re: Question re milk thistleand tyrosine > To the best of my knowledge tyrosine has no impact on blood pressure. It > is > a precursor necessary for the production of dopamine by the liver. It is > quite beneficial. Salt and sugar as well as poor diets have more impact on > BP . > Hope this helps. > If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of > walking I've been doing the last few days fixing storm damage on the ranch > fences. Needless to say by sundown I'm really wornout for the day. > Have a good Sunday Ray. > > ----- Original Message ----- > From: "rayilynlee" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Friday, May 08, 2009 10:48 AM > Subject: Re: Question re milk thistle > > >> thanks Roberta - I take bp medication >> Ray >> >> Rayilyn Brown >> Director AZNPF >> Arizona Chapter National Parkinson Foundation >> [log in to unmask] >> >> -------------------------------------------------- >> From: <[log in to unmask]> >> Sent: Thursday, May 07, 2009 4:03 AM >> To: <[log in to unmask]> >> Subject: Re: Question re milk thistle >> >> > >> > >> > Doesn't Tyrosine increase blood pressure? >> > >> > Roberta Innarella >> > >> > >> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, >> > [log in to unmask] writes: >> > >> > Yep! >> > >> > ----- Original Message ----- >> > From: "rayilynlee" <[log in to unmask]> >> > To: <[log in to unmask]> >> > Sent: Tuesday, May 05, 2009 9:45 AM >> > Subject: Re: Question re milk thistle >> > >> > >> >> gee, I didn't know milk thistle would help my liver produce dopamine. >> >> I >> >> started taking it for constipation. Do I need to take tyrosine with > it? >> >> >> >> Ray >> >> >> >> Rayilyn Brown >> >> Director AZNPF >> >> Arizona Chapter National Parkinson Foundation >> >> [log in to unmask] >> >> >> >> -------------------------------------------------- >> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> >> >> Sent: Tuesday, May 05, 2009 8:40 AM >> >> To: <[log in to unmask]> >> >> Subject: Question re Amantadine/ GSH importance >> >> >> >> > Couple of thoughts. >> >> > Have you tried to let your liver produce your dopamine needs by > taking >> >> > tyrosine and milk thistle? >> >> > The natural production of GSH by the body is a little more >> > complicated >> >> > but >> >> > following is article from my archives that helps explain. >> >> > WHY GSH >> >> > Oxidative stress appears to play an important role in degeneration > of >> >> > dopaminergic neurons of the substantia nigra (SN) associated with >> >> > Parkinson's disease (PD). The SN of early PD patients have >> >> > dramatically >> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH > plays >> >> > multiple roles in the nervous system both as an antioxidant and a >> >> > redox >> >> > modulator. We have generated dopaminergic PC12 cell lines in which >> > levels >> >> > of >> >> > GSH can be inducibly down-regulated via doxycycline induction of >> > antisense >> >> > messages against both the heavy and light subunits of >> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in >> >> > glutathione >> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase results > in >> >> > reduction in mitochondrial GSH levels, increased oxidative stress, > and >> >> > decreased mitochondrial function. Interestingly, decreases in >> >> > mitochondrial >> >> > activities in GSH-depleted PC12 cells appears to be because of a >> > selective >> >> > inhibition of complex I activity as a result of thiol oxidation. > These >> >> > results suggest that the early observed GSH losses in the SN may >> >> > be >> >> > directly >> >> > responsible for the noted decreases in complex I activity and the >> >> > subsequent >> >> > mitochondrial dysfunction, which ultimately leads to dopaminergic >> >> cell >> >> > death >> >> > associated with PD. >> >> > >> >> > WHY GLUTAMINE >> >> > Glutamine is an important mitochondrial substrate implicated in the >> >> > protection of cells from oxidant injury. Human pulmonary >> > epithelial-like >> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence and >> >> > presence >> >> > of glutamine. Cell proliferation in normoxia was dependent on >> > glutamine, >> >> > and >> >> > glutamine deprivation markedly accelerated cell death in hyperoxia. >> >> > Glutamine significantly increased cellular ATP levels in normoxia > and >> >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived >> > cells. >> >> > Mitochondrial membrane potential as assessed by flow cytometry with >> >> > chloromethyltetramethylrosamine was increased by glutamine in >> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent > increase >> > in >> >> > mitochondrial membrane potential was detected. > Glutamine-supplemented, >> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and GSH >> >> > content. >> >> > Electron and fluorescence microscopy revealed that, in hyperoxia, >> >> > glutamine >> >> > protected cellular structures, especially mitochondria, from >> >> > damage. >> >> > In >> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme >> >> > alpha-ketoglutarate dehydrogenase was partially protected by its >> > indirect >> >> > substrate, glutamine, indicating a mechanism of mitochondrial >> > protection. >> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of >> >> > GSH >> >> > in >> >> > the >> >> > body naturally to further thwart the symptoms and destruction of > P.D. >> >> > along >> >> > with my other vitamin/mineral protocol which exclude PD drugs. As a >> > note. >> >> > I >> >> > never tried the Amantadine. My doctors forced me early to look >> > elsewhere >> >> > for >> >> > help since they couldnt due to lack of knowledge or incentive. Not >> >> > sure >> >> > which but I'm alot healthier for switching to a no drug protocol. >> >> > >> >> > ----- Original Message ----- >> >> > From: "Ernesto Divo" <[log in to unmask]> >> >> > To: <[log in to unmask]> >> >> > Sent: Sunday, May 03, 2009 12:24 PM >> >> > Subject: Re: Question re Amantadine use >> >> > >> >> > >> >> >> Hi John, >> >> >> >> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect >> >> >> and >> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. I > have >> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a >> >> > supplement >> >> >> developed here in the US, by a US scientist and sold by a US >> >> >> company. It raises thet levels of GSH in your cells naturally. It >> >> >> took >> >> >> the >> >> >> GXL about a week to work on my sleeping pattern, I was waking up > 2-3 >> >> >> times >> >> >> during the night, now I sleep straight thru the night, and it took >> > about >> >> >> three weeks to work on my cognitive process but it was so subtle >> >> >> I >> > barely >> >> >> thought it was the GXL. I wasn't having problems looking for words > to >> >> > finish >> >> >> a sentence, my memory is back, I don't lose things around the > house, >> > I >> >> > have >> >> >> more energy and I feel good and my wife is happier. It is >> >> >> strange, >> > when >> >> >> I >> >> >> asked my doctor about it he said Gluta what? it seems the >> >> medical >> >> > community >> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't > want >> >> >> competition... I order mine from www.maxgxl.com/133282 I >> >> >> suggest >> >> >> getting >> >> >> as much info as possible of GSH, I went to www.youtube.com and >> > searched >> >> > for >> >> >> 'The mother of all antioxidants', there is this doctor Mark Hyman > who >> >> >> explains in details about GSH; excellent video. >> >> >> >> >> >> Good luck to you. >> >> >> >> >> >> Ernesto, >> >> >> Miami, FL >> >> >> >> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys > <[log in to unmask]> >> >> > wrote: >> >> >> >> >> >> > Hey John >> >> >> > >> >> >> > I've been on Amantadine since being diagnosed in October of >> >> last >> > year; >> >> >> > dosage has remained constant and titrated from 100mg to 300mg >> >> >> > per >> > day, >> >> > over >> >> >> > an initial period of 3 weeks. >> >> >> > >> >> >> > I space the dosing about 5-ish hours apart; I've found if the > final >> >> >> > dose >> >> > of >> >> >> > 100mg is taken later than 8PM, I have trouble sleeping through > the >> >> > night. >> >> >> > >> >> >> > It does give me an energy boost and some minor relief from > muscle >> >> >> > tightness, but does nothing to improve gait or reduce tremor. > It's >> > sort >> >> > of >> >> >> > just a little bit of "gas" for your "engine." >> >> >> > >> >> >> > On the other hand, I find it causes auditory hallucinations, >> >> >> > drowsiness, >> >> >> > occasional vertigo, foggy thought processing and swelling around >> > the >> >> > knees. >> >> >> > >> >> >> > I find much better results on GSH and mucuna bean, which I > started >> >> >> > about >> >> > 6 >> >> >> > months ago (the mucuna has been a very recent thing, so it's >> >> >> > been >> > too >> >> > early >> >> >> > to tell – but so far, I'm definitely impressed). My neuro >> > practically >> >> > lit >> >> >> > his own hair on fire when I told him, but he couldn't deny the >> > results >> >> > of >> >> >> > the GSH. >> >> >> > >> >> >> > The goal is to be able to cut the amantadine by 35 - 50% within >> >> >> > 6 >> >> > months. >> >> >> > My view is the longer I stay away from starting the agonists, > the >> >> > better. >> >> >> > >> >> >> > Hope that helps. >> >> >> > >> >> >> > >> >> >> > >> >> >> > Joh >> >> >> > >> >> >> > >> >> >> >> >> >> > ---------------------------------------------------------------------- >> >> >> > To sign-off Parkinsn send a message to: mailto: >> >> >> > [log in to unmask] >> >> >> > In the body of the message put: signoff parkinsn >> >> >> > >> >> >> >> >> >> >> >> >> ---------------------------------------------------------------------- >> >> >> To sign-off Parkinsn send a message to: >> >> > mailto:[log in to unmask] >> >> >> In the body of the message put: signoff parkinsn >> >> > >> >> > ---------------------------------------------------------------------- >> >> > To sign-off Parkinsn send a message to: >> >> > mailto:[log in to unmask] >> >> > In the body of the message put: signoff parkinsn >> >> >> >> >> > ---------------------------------------------------------------------- >> >> To sign-off Parkinsn send a message to: >> > mailto:[log in to unmask] >> >> In the body of the message put: signoff parkinsn >> &> >> > ---------------------------------------------------------------------- >> > To sign-off Parkinsn send a message to: mailto:[log in to unmask] >> > oronto.ca >> > In the body of the message put: signoff parkinsn >> > >> > >> > >> > >> > **************Remember Mom this Mother's Day! 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