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Has anyone had any luck with CoQenzyme 10 ? I heard large doses 1200 + mg daily might slow progression of PD Suzanne EMAILING FOR THE GREATER GOOD Join me > Date: Sun, 10 May 2009 11:23:31 -0400 > From: [log in to unmask] > Subject: Re: Question re milk thistleand tyrosine > To: [log in to unmask] > > > > > The following taken from "Prescription for Nutritional Healing" Third > Edition: > > "Tyrosine is important to overall metabolism. It is a precursor of > adrenaline and the neurotransmiters norepinephrine and dopamine, which regulate > mood and stimulate metabolism and the nervous system. Tyrosine acts as a > mood elevator; a lack of adequate amounts of tyrosine leads to a deficiency > of norepinephrine in the brain, which in turn can result in depression. It > also acts as a mild antioxidant, suppresses the appetite, and helps to > reduce body fat. It aids in the production of melanin (the pigment responsible > for skin and hair color) and in the functions of the adrenal, thyroid, and > pituitary glands. It is also involved in the metabolism of the amino acid > phenylalanine. > > Tyrosine attaches to iodine atoms to form active thyroid hormones. Not > surprisingly, therefore, low plasma levels of tyrosine have been associated > with hypothyroidism. Symptoms of tyrosine deficiency can also include low > blood pressure, low body temperature (such as cold hands and feet), and > restless leg syndrome. > > Supplemental L-tyrosine has been used for stress reduction, and research > suggests it may be helpful against chronic fatigue and narcolepsy. It has > been used to help individuals suffering from anxiety, depression, low sex > drive, allergies, and headaches, as well as persons undergoing withdrawal > from drugs. It may also help people with Parkinson's disease. > > Natural resources of tyrosine include almonds, avocados, bananas, dairy > products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine can also be > produced from phenylalanine in the body. Supplements of L-tyrosine should > be taken at bedtime or with a high-carbohydrate meal so that it does not > have to complete for absorption with other amino acids. > > Persons taking monoamine oxidase (MAO)) inhibitors, commonly prescribed > for depression, must strictly limit their intake of foods containing tyrosine > and should not take any supplements containing L-tyrosine, as it may lead > to a sudden and dangerous rise in blood pressure. Anyone who takes > prescription medication for depression should discuss necessary dietary > restrictions with his or her physician." > > I take Azilect which is an MOA (B) not (A) inhibitor so I don't know if > the last paragraph would apply as I obviously don't take it for depression > but for PD. I guess I'll need to research further unless anyone on this > forum knows the answer. > > Roberta Innarella > > > In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time, > [log in to unmask] writes: > > Schaff: > > I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the > correct > amount or not? > thanks so much and for clarifying the bp issue. I couldn't find anything > > on line that said tyrosine caused high bp - and yes it did claim these 2 > supplements as treatment for PD. thanks so very much > > here's hoping....I don't take PD meds you know, but am getting worse > > Ray > > Rayilyn Brown > Director AZNPF > Arizona Chapter National Parkinson Foundation > [log in to unmask] > > -------------------------------------------------- > From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> > Sent: Sunday, May 10, 2009 8:09 PM > To: <[log in to unmask]> > Subject: Re: Question re milk thistleand tyrosine > > > To the best of my knowledge tyrosine has no impact on blood pressure. It > > is > > a precursor necessary for the production of dopamine by the liver. It is > > quite beneficial. Salt and sugar as well as poor diets have more impact > on > > BP . > > Hope this helps. > > If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of > > walking I've been doing the last few days fixing storm damage on the > ranch > > fences. Needless to say by sundown I'm really wornout for the day. > > Have a good Sunday Ray. > > > > ----- Original Message ----- > > From: "rayilynlee" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Friday, May 08, 2009 10:48 AM > > Subject: Re: Question re milk thistle > > > > > >> thanks Roberta - I take bp medication > >> Ray > >> > >> Rayilyn Brown > >> Director AZNPF > >> Arizona Chapter National Parkinson Foundation > >> [log in to unmask] > >> > >> -------------------------------------------------- > >> From: <[log in to unmask]> > >> Sent: Thursday, May 07, 2009 4:03 AM > >> To: <[log in to unmask]> > >> Subject: Re: Question re milk thistle > >> > >> > > >> > > >> > Doesn't Tyrosine increase blood pressure? > >> > > >> > Roberta Innarella > >> > > >> > > >> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time, > >> > [log in to unmask] writes: > >> > > >> > Yep! > >> > > >> > ----- Original Message ----- > >> > From: "rayilynlee" <[log in to unmask]> > >> > To: <[log in to unmask]> > >> > Sent: Tuesday, May 05, 2009 9:45 AM > >> > Subject: Re: Question re milk thistle > >> > > >> > > >> >> gee, I didn't know milk thistle would help my liver produce > dopamine. > >> >> I > >> >> started taking it for constipation. Do I need to take tyrosine with > > it? > >> >> > >> >> Ray > >> >> > >> >> Rayilyn Brown > >> >> Director AZNPF > >> >> Arizona Chapter National Parkinson Foundation > >> >> [log in to unmask] > >> >> > >> >> -------------------------------------------------- > >> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]> > >> >> Sent: Tuesday, May 05, 2009 8:40 AM > >> >> To: <[log in to unmask]> > >> >> Subject: Question re Amantadine/ GSH importance > >> >> > >> >> > Couple of thoughts. > >> >> > Have you tried to let your liver produce your dopamine needs by > > taking > >> >> > tyrosine and milk thistle? > >> >> > The natural production of GSH by the body is a little more > >> > complicated > >> >> > but > >> >> > following is article from my archives that helps explain. > >> >> > WHY GSH > >> >> > Oxidative stress appears to play an important role in degeneration > > of > >> >> > dopaminergic neurons of the substantia nigra (SN) associated with > >> >> > Parkinson's disease (PD). The SN of early PD patients have > >> >> > dramatically > >> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH > > plays > >> >> > multiple roles in the nervous system both as an antioxidant and a > >> >> > redox > >> >> > modulator. We have generated dopaminergic PC12 cell lines in > which > >> > levels > >> >> > of > >> >> > GSH can be inducibly down-regulated via doxycycline induction of > >> > antisense > >> >> > messages against both the heavy and light subunits of > >> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in > >> >> > glutathione > >> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase results > > in > >> >> > reduction in mitochondrial GSH levels, increased oxidative > stress, > > and > >> >> > decreased mitochondrial function. Interestingly, decreases in > >> >> > mitochondrial > >> >> > activities in GSH-depleted PC12 cells appears to be because of a > >> > selective > >> >> > inhibition of complex I activity as a result of thiol oxidation. > > These > >> >> > results suggest that the early observed GSH losses in the SN may > >> >> > be > >> >> > directly > >> >> > responsible for the noted decreases in complex I activity and the > >> >> > subsequent > >> >> > mitochondrial dysfunction, which ultimately leads to dopaminergic > >> >> cell > >> >> > death > >> >> > associated with PD. > >> >> > > >> >> > WHY GLUTAMINE > >> >> > Glutamine is an important mitochondrial substrate implicated in > the > >> >> > protection of cells from oxidant injury. Human pulmonary > >> > epithelial-like > >> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence > and > >> >> > presence > >> >> > of glutamine. Cell proliferation in normoxia was dependent on > >> > glutamine, > >> >> > and > >> >> > glutamine deprivation markedly accelerated cell death in > hyperoxia. > >> >> > Glutamine significantly increased cellular ATP levels in normoxia > > and > >> >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived > >> > cells. > >> >> > Mitochondrial membrane potential as assessed by flow cytometry > with > >> >> > chloromethyltetramethylrosamine was increased by glutamine in > >> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent > > increase > >> > in > >> >> > mitochondrial membrane potential was detected. > > Glutamine-supplemented, > >> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and > GSH > >> >> > content. > >> >> > Electron and fluorescence microscopy revealed that, in > hyperoxia, > >> >> > glutamine > >> >> > protected cellular structures, especially mitochondria, from > >> >> > damage. > >> >> > In > >> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme > >> >> > alpha-ketoglutarate dehydrogenase was partially protected by its > >> > indirect > >> >> > substrate, glutamine, indicating a mechanism of mitochondrial > >> > protection. > >> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of > >> >> > GSH > >> >> > in > >> >> > the > >> >> > body naturally to further thwart the symptoms and destruction of > > P.D. > >> >> > along > >> >> > with my other vitamin/mineral protocol which exclude PD drugs. As > a > >> > note. > >> >> > I > >> >> > never tried the Amantadine. My doctors forced me early to look > >> > elsewhere > >> >> > for > >> >> > help since they couldnt due to lack of knowledge or incentive. > Not > >> >> > sure > >> >> > which but I'm alot healthier for switching to a no drug > protocol. > >> >> > > >> >> > ----- Original Message ----- > >> >> > From: "Ernesto Divo" <[log in to unmask]> > >> >> > To: <[log in to unmask]> > >> >> > Sent: Sunday, May 03, 2009 12:24 PM > >> >> > Subject: Re: Question re Amantadine use > >> >> > > >> >> > > >> >> >> Hi John, > >> >> >> > >> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking > Azilect > >> >> >> and > >> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. I > > have > >> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', > a > >> >> > supplement > >> >> >> developed here in the US, by a US scientist and sold by a US > >> >> >> company. It raises thet levels of GSH in your cells naturally. It > >> >> >> took > >> >> >> the > >> >> >> GXL about a week to work on my sleeping pattern, I was waking up > > 2-3 > >> >> >> times > >> >> >> during the night, now I sleep straight thru the night, and it > took > >> > about > >> >> >> three weeks to work on my cognitive process but it was so > subtle > >> >> >> I > >> > barely > >> >> >> thought it was the GXL. I wasn't having problems looking for > words > > to > >> >> > finish > >> >> >> a sentence, my memory is back, I don't lose things around the > > house, > >> > I > >> >> > have > >> >> >> more energy and I feel good and my wife is happier. It is > >> >> >> strange, > >> > when > >> >> >> I > >> >> >> asked my doctor about it he said Gluta what? it seems the > >> >> medical > >> >> > community > >> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't > > want > >> >> >> competition... I order mine from www.maxgxl.com/133282 I > >> >> >> suggest > >> >> >> getting > >> >> >> as much info as possible of GSH, I went to www.youtube.com and > >> > searched > >> >> > for > >> >> >> 'The mother of all antioxidants', there is this doctor Mark Hyman > > who > >> >> >> explains in details about GSH; excellent video. > >> >> >> > >> >> >> Good luck to you. > >> >> >> > >> >> >> Ernesto, > >> >> >> Miami, FL > >> >> >> > >> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys > > <[log in to unmask]> > >> >> > wrote: > >> >> >> > >> >> >> > Hey John > >> >> >> > > >> >> >> > I've been on Amantadine since being diagnosed in October of > >> >> last > >> > year; > >> >> >> > dosage has remained constant and titrated from 100mg to 300mg > >> >> >> > per > >> > day, > >> >> > over > >> >> >> > an initial period of 3 weeks. > >> >> >> > > >> >> >> > I space the dosing about 5-ish hours apart; I've found if the > > final > >> >> >> > dose > >> >> > of > >> >> >> > 100mg is taken later than 8PM, I have trouble sleeping through > > the > >> >> > night. > >> >> >> > > >> >> >> > It does give me an energy boost and some minor relief from > > muscle > >> >> >> > tightness, but does nothing to improve gait or reduce tremor. > > It's > >> > sort > >> >> > of > >> >> >> > just a little bit of "gas" for your "engine." > >> >> >> > > >> >> >> > On the other hand, I find it causes auditory hallucinations, > >> >> >> > drowsiness, > >> >> >> > occasional vertigo, foggy thought processing and swelling > around > >> > the > >> >> > knees. > >> >> >> > > >> >> >> > I find much better results on GSH and mucuna bean, which I > > started > >> >> >> > about > >> >> > 6 > >> >> >> > months ago (the mucuna has been a very recent thing, so it's > >> >> >> > been > >> > too > >> >> > early > >> >> >> > to tell – but so far, I'm definitely impressed). My neuro > >> > practically > >> >> > lit > >> >> >> > his own hair on fire when I told him, but he couldn't deny > the > >> > results > >> >> > of > >> >> >> > the GSH. > >> >> >> > > >> >> >> > The goal is to be able to cut the amantadine by 35 - 50% > within > >> >> >> > 6 > >> >> > months. > >> >> >> > My view is the longer I stay away from starting the agonists, > > the > >> >> > better. > >> >> >> > > >> >> >> > Hope that helps. > >> >> >> > > >> >> >> > > >> >> >> > > >> >> >> > Joh > >> >> >> > > >> >> >> > > >> >> >> > >> > >> >> > > ---------------------------------------------------------------------- > >> >> >> > To sign-off Parkinsn send a message to: mailto: > >> >> >> > [log in to unmask] > >> >> >> > In the body of the message put: signoff parkinsn > >> >> >> > > >> >> >> > >> >> > >> >> >> > >> ---------------------------------------------------------------------- > >> >> >> To sign-off Parkinsn send a message to: > >> >> > mailto:[log in to unmask] > >> >> >> In the body of the message put: signoff parkinsn > >> >> > > >> >> > > ---------------------------------------------------------------------- > >> >> > To sign-off Parkinsn send a message to: > >> >> > mailto:[log in to unmask] > >> >> > In the body of the message put: signoff parkinsn > >> >> > >> > >> >> > > ---------------------------------------------------------------------- > >> >> To sign-off Parkinsn send a message to: > >> > mailto:[log in to unmask] > >> >> In the body of the message put: signoff parkinsn > >> &> > >> > ---------------------------------------------------------------------- > >> > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > >> > oronto.ca > >> > In the body of the message put: signoff parkinsn > >> > > >> > > >> > > >> > > >> > **************Remember Mom this Mother's Day! Find a florist near you > > now. > >> > > > > (http://yellowpages.aol.com/search?query=florist&ncid=emlcntusyelp00000006) > >> > > >> > ---------------------------------------------------------------------- > >> > To sign-off Parkinsn send a message to: > >> > mailto:[log in to unmask] > >> > In the body of the message put: signoff parkinsn > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > > > > **************Recession-proof vacation ideas. 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