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 from Viartis

 9 July 2009

 INTERFERING WITH GLUTAMATE TO PREVENT PARKINSON'S DISEASE

It has been widely reported that researchers are aiming to interfere with 
the formation of Glutamate in order to prevent Parkinson's Disease. For the 
news reports go to Medical News Today and Science Daily. The research was 
recently presented at a conference. Glutamate is able to form GABA in the 
brain. GABA is a chemical produced naturally by the brain, that affects 
muscular function. An excess of GABA could provoke symptoms of Parkinson's 
Disease.  The researchers aim to stimulate "trigger points" in order to 
prevent the release of glutamate. By targeting specific receptors they hope 
that side-effects will be minimised as fewer targets elsewhere in the brain 
will be stimulated. They claim that glutamate causes cell death in 
Parkinson's Disease. However, glutamate formation is a healthy function, and 
has never been shown, in normal quantities, to cause cell death in people 
with Parkinson's Disease. The fundamental weakness in their theory is that 
glutamate has never been responsible for causing Parkinson's Disease when 
dopamine formation is sufficient either.  The primary biochemical fault in 
Parkinson's Disease has been proven to be the insufficient formation of 
dopamine rather than an excess of glutamate. Yet the approach used by the 
researchers could not, even in theory, increase dopamine formation.  In 
order to refer to this article on its own click here.

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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