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Thanks, Rick. Here's a double-blind study. Kathleen A double-blind evaluation of electroconvulsive therapy in Parkinson's disease with "on-off" phenomena K. Andersen1, J. Balldin2,*<http://www3.interscience.wiley.com/journal/121522665/abstract?CRETRY=1&SRETRY=0#c1>, C.G. Gottfries2, A-K. Granérus1, K. Modigh2, L. Svennerholm2 A. Wallin2 1Department of Geriatric and Long-term Care Medicine, Vasa Hospital, Gothenburg, Sweden. 2Department of Psychiatry and Neurochemistry, St. Jörgen's Hospital, Hisings Backa, Sweden. Correspondence to *Dr. Jan Balldin Department of Psychiatry and Neurochemistry St. Jörgen's Hospital S–422 03 Hisings Backa, Sweden Copyright 1987 Blackwell Munksgaard KEYWORDS electroconvulsive therapy • Parkinson's disease • on-off phenomena • monoamine metabolites ABSTRACT Abstract— Eleven patients with severe Parkinson's disease and on-off-phenomena were included in a controlled double-blind study on the effect of electroconvulsive therapy (ECT). Pharmacological treatment was optimally adjusted before the trial. The severity of extrapyramidal symptoms was measured before, during and after the treatment. The patients were randomly allocated into one group, receiving active ECT and another, receiving sham treatment. The patients given active ECT showed significantly (P < 0.05) prolonged duration of "on"-phases after ECT, in comparison to the sham-treated group. When collecting data from the controlled part of the study and the subsequent with open administration of ECT, the treatment was in addition found to significantly decrease the time and number of steps required to walk 10 meters. Moreover it reduced the severity of parkinsonian symptoms according to the Webster scale. The improvement induced by ECT was generally short-lasting. Lumbar punctures were performed before and after ECT. The concentrations of mcnoamine metabolites in cerebrospinal fluid were not affected by the treatment. The results indicate that ECT has an antiparkinsonian effect which probably is mediated via changed responsiveness of dopamine receptors and that further improvement is possible in patients, therapy resistant to the presently available medication. ------------------------------ Accepted for publication April 21, 1987. 2009/7/12 Rick Everett <[log in to unmask]> > Full text is available- > > > 1: J Neuropsychiatry Clin Neurosci. 2003 Fall;15(4):407-21. > > Electroconvulsive therapy in movement disorders: an update. > > Kennedy R, Mittal D, O'Jile J. > > Department of Psychiatry, University of Missippi Medical Center, Jackson, > USA. > [log in to unmask] > > Electroconvulsive therapy (ECT) is a well-recognized treatment for > psychiatric > illness, primarily depressive disorders. Its use in patients with > neurological > illnesses is steadily increasing. Older reviews indicate that ECT may also > benefit Parkinson's disease and similar movement disorders independent of > its > effects on comorbid psychiatric disorders. In this updated review, recent > literature regarding ECT and movement disorders is summarized from 1990 to > 2000. > Considerable evidence indicates that ECT improves motor symptoms of > Parkinson's > disease in patients with and without mood disorders. A few case reports, > ranging > from one to six patients per disorder, suggest that ECT may ameliorate the > motor > symptoms of other movement disorders. ECT affects a variety of > neurotransmitters > that play a role in these diseases. Limitations of current reports are > reviewed, > and recommendations for further investigation are made. > > > PMID: 14627767 [PubMed - indexed for MEDLINE] > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn