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Exercise May Lead To Improvement In Patients With Parkinson's - USC Study On Dopamine Effects Shows Potential Benefits In Balance And Stability Filed under: Uncategorized - betweenmodeling @ 5:34 am A new study from researchers at the Keck Infuse with of Medicine of the University of Southern California (USC) shows that treadmill exercises may benefit patients with Parkinson's Ailment and those with similar trend disorders. The swot is led by USC neuroscientist Michael Jakowec, Ph.D., assistant professor of neurology and appears in the May 16 issue of the Weekly of Neuroscience. Recent studies take shown that performance can have advantageous effects in patients with Parkinson's Disease but the underlying reasons haven't been fully explored. This fresh study using treadmill exercise in animal models looked at the effects of dopamine in motor erudition and touch. Parkinson's Disease is a chronic and degenerative sickness that leads to slowness, balance disorders, tremors and jam in walking. The malady results from the destruction of dopamine-producing irritate cells in the planner. It is touch-and-go as a stimulator of motor system nerves in the assembly. While there is no au courant panacea for the disease, several treatments do offer relief from its symptoms. This particular study looked at treadmill exercise and its effects between animal models with and without a loss of certain cells that are like to what a Parkinson's Patient might suffer. Given the importance of dopamine in Parkinson's Disease, the researchers looked at changes in dopamine levels, among other results. They found that the subjects with cell bereavement and that exercised indeed had an effect on dopamine levels while normal subjects showed less of a leftovers in levels. "Our study shows that the beneficial effects of exercise in Parkinson's Disease may be scheduled to a more efficient use of dopamine, "says Giselle Petzinger, M.D., assistant professor of neurology at the Keck High school of Medicine of USC and the study's elementary author. "Surviving dopamine cells in our animal models- made to simulate what Parkinson's patients suffer with- subjected to intensive treadmill exercise appear to work harder." Studies with John Walsh, Ph.D., associate professor at the USC Andrus Gerontology Center and a co-investigator of the study, showed that these cells release greater amounts of dopamine and abatement the rate of its removal from the synapse compared to neurons in subjects that do not undergo exercise. The findings suggest that the benefits of treadmill put to use on motor performance may be accompanied by changes in dopamine neurotransmission that are sundry in the injured subjects compared to the non-injured. "Studies in our zoological example of Parkinson's infirmity support the to be sure that exercise is beneficial for patients with Parkinson's," says Jakowec. "Exercise may mitigate the injured capacity to bring into play function more efficiently by allowing the remaining dopamine producing neurons to work harder and in doing so may promote stronger connections in the brain." Further studies will examine if beneficial effects of exercise have long-term effect on the injured brain, identifying the molecular links between exercise and the brain, and to better understand the molecular mechanisms within neurons that lead to these changes. Funding for this study comes from the Parkinson's Disease Foundation, Link up Parkinson Los Angeles, the George and MaryLou Boone Groundwork, the Popular Institute of Neurological Disorders and Act and the US Army Neurotoxin Acquaintance Treatment Research Program. "Effects of Treadmill Drill on Dopaminergic Transmission in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Model of Basal Ganglia Injury" Petzinger, G.,Walsh, J.,Akopian, G., Hogg, E., Abernathy, A., Arevalo, P.,Turnquist, P., Vuckovic, M., Fisher, B.,Togasaki, D., Jakowec, M. Yearbook of Neuroscience, May 16, 2007. http://www.usc.edu Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn