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Just found this...more serious fx, though if none of these conditions pertains, it seems to me that budipine still might be a good choice and could add one more stop on the way to DBS. Kathleen http://apps.who.int/medicinedocs/fr/d/Jh1466e/2.6.html#Jh1466e.2.6 Budipine - revised data sheet: cardiac adverse reactions *Germany.* The manufacturer of the antiparkinsonian agent, budipine (Parkinsan®: Byk Gulden Lomberg and Lundbeck) has revised the product information for this product to extend the contraindications to include patients with cardiomyopathy, myocarditis and AV Block II and III as well as patients with a history of ventricular arrhythmia, especially tachycardia (torsade de pointes). In addition an electrocardiogram should be performed before the start of therapy, then again one to three weeks afterwards and on increase of the dosage. Patients with a QTc value over 420 ms or discernible U-waves, or with an increase in QTc of over 60 ms and accordingly a QTc time of over 480 ms and discernible U-waves when taking budipine are excluded from treatment. As regards risk factors for electrolyte imbalance, e.g. diuretic medication, frequent vomiting and/or diarrhoea, use of insulin in an emergency, kidney disease or anorexia, laboratory tests should be performed, especially for potassium and magnesium. As soon as symptoms such as palpitations, dizziness or syncope appear, budipine must be withdrawn and, if necessary, the patient examined for QT-prolongation. This action was taken in the context of the ongoing review of marketed products carried out by the Federal Institute for Drugs and Medical Devices which found that the incidence of cardiac adverse reactions was not adequately reflected in the product information. *References: Deutsche Apotheker Zeitung 140(41): 4662 (2000).* [image: Afficher le document]<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.1.html>Safety of Herbal medicines - Discussion at the 23rd meeting of national drug monitoring centres, Tunisia, November 2000<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.1.html> [image: Afficher le document]<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.2.html>Effects of paracetamol pack size restriction on overdose<http://apps.who.int/medicinedocs/fr/d/Jh1466e/4.2.html> 2009/10/1 Kathleen Cochran <[log in to unmask]> > More about the "new" treatment, budipine...new in 1986, that is. Why is > this not part of the accepted regimen for tremor dominant PD? Does the lower > case "b" mean that perhaps no one makes much money from it? > > http://www.springerlink.com/content/q65m76n526027107/ > > Kathleen > > 2009/10/1 rayilynlee <[log in to unmask]> > > Rayilyn Brown >> Director AZNPF >> Arizona Chapter National Parkinson Foundation >> [log in to unmask] >> >> >> From: Diane Wyshak >> Sent: Wednesday, September 30, 2009 11:31 AM >> To: ray ; chew Nee Kong >> Subject: Good and bad news for Tremor dominant wpd - NeuroTalk Communities >> >> >> >> http://neurotalk.psychcentral.com/showthread.php?t=104263 >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: mailto: >> [log in to unmask] >> In the body of the message put: signoff parkinsn >> > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn