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Depemding on the source of the report, you get very different views of the significance of this study. I think the best objective analysis i've seen is the Fox Foundation's News in Context : "From Teva's ADAGIO Trial: Inconclusive Results, but Possible Disease-modifying Effect, for Azilect (Rasagiline) "This week, the New England Journal of Medicine published data from the ADAGIO Phase 3 clinical trial of Israeli drugmaker Teva’s Azilect (rasagiline). The trial was designed to test whether Azilect, which is already approved for symptomatic treatment of Parkinson’s, may also have a disease-modifying effect. For early-stage PD patients, a 1-milligram dose of Azilect met all three clinical endpoints for disease modification. However, a 2-milligram dosage met only two of three endpoints. Because of this inconsistency, we cannot definitively conclude that the drug has disease-modifying effects. The Michael J. Fox Foundation spoke with Karl Kieburtz, MD, MPH, about how patients should interpret the news." see full article at: http://www.michaeljfox.org/research_viewpoints_newsInContext_article.cfm?ID=15 there has also been a lively discussion about this study on the Fox Foundagion's PD Online research forum: http://www.pdonlineresearch.org/news/2009-09/23/results-adagio-trial-rasagiline-suggest-possible-disease-modifying-effect www.pdpipeline.org ---------- Original Message ---------- From: Scott Burnett <[log in to unmask]> To: [log in to unmask] Subject: Re: NEJM Throws Cold Water on Aztilect Study Findings Maybe not1 Date: Fri, 2 Oct 2009 07:52:52 -0700 Actually if you read the abstract of the trial and Teva's commenfs on the trial, Teva cautioned not to over estimate the results, mainly due to the 1 mg/2 mg question. The abstract seemed to me to make a solid case for the 1 mg dosage maybe slowing the progresssion of PD. As best as I can understand it the researchers are confused as to why if 1 mg was good, why wasn't 2 mg twice as good! Heck I don't care why it happened. I just want something that slows down this damn disease, not another drug that alleviates the syptoms and then wears off (not to mention the side effects!) Scott Burnett 7715 Heather Dr. Stockton, CA 95297 209-478-9328 [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn