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Esther, Yes, Stalevo is simply Sinemet and Comtan combined in one tablet. Your husband may be responding badly to the Comtan (which I assume he had not taken before) or the particular dosages of the two drugs in his Stalevo may not be optimum for him. I suppose you could try various combinations of the two taken separately. My wife (31 years with PD) takes Sinemet every two hours from 6:30 a.m. until 8:30 p.m. and Comtan with four of these administrations. The purpose of Comtan is to increase the effectiveness of the Sinemet. Is your physician a movement-disorder specialist? Is he willing and able to describe to you what he is doing and why? If not, I recommend getting still another new doctor. Best wishes, -Ken On Wed, Oct 21, 2009 at 4:08 PM, <[log in to unmask]> wrote: > My husband has been prescribed Stalevo (he has late-stage Parkinsons.) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn