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Stalevo is simply carbidopa-levodopa (= Sinemet) plus entacapone (= Comtan). My PD doc switched me last summer, but I went back to Sinemet after a few weeks with no change. The biggest difference was that Stalevo is not generic, and costs many more $$ than Sinemet. Tony In a message dated 10/22/2009 2:10:25 A.M. Eastern Daylight Time, [log in to unmask] writes: My husband has been prescribed Stalevo (he has late-stage Parkinsons.) A new doctor has taken away his long-time drugs: mirapex, Sinemet CR (ER) and is gradually removing his carbidopa/levodopa. These meds changes have brought a quite rapid deterioration on all fronts. I'm interested if anyone has any experience with Stalevo, positive or negative. If so, could you write about it on this list-serv.. I haven't posted in some years-- the list-serv appears to have been hi-jacked by politics and perhaps there is no one on it any more who is concerned about these actual Parkinsons clinical issues. Anyway, if there still is, could you post? Thanks, Esther ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn