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I'm with you all the way John! I think after a few years most of us read articles like this with a lot of skepticism... Nic 57/15 On Wed, Nov 4, 2009 at 7:07 PM, john thomas <[log in to unmask]> wrote: > I don't wish to be super negative but one must stop and question all > sources > of information and claims that supposedly occur related to PD cures. > This article falls down in the first paragraph in that its model is assume > to be "simulated but asymptomatic Parkinson's disease ". I would argue what > the hell that is supposed to mean before I went on and read the article. I > don't wish to can what in effect appears to be great research but it > appears > to me that every research fund searching group tacks on an added "oh it > will > also cure Pd "clause. > There are many either erroneous or at least presumptuous remarks , that > would require further techniques knowledge , before I can comment further > but it just bugs me that every time a researcher has a flash of > inspiration > it triggers such media related response. > -----Original Message----- > > John thomas BAps MR > > > From: Parkinson's Information Exchange Network > [mailto:[log in to unmask]] On Behalf Of Nic Marais > Sent: Tuesday, November 03, 2009 8:24 AM > To: [log in to unmask] > Subject: Researchers find brain cell transplants help repair neural damage > > A Swiss research team has found that using an animal's own brain cells > (autologous transplant) to replace degenerated neurons in select brain > areas > of donor primates with simulated but asymptomatic Parkinson's disease and > previously in a motor cortex lesion model, provides a degree of brain > protection and may be useful in repairing brain lesions and restoring > function. > "We aimed at determining whether autografted cells derived from cortical > grey matter, cultured for one month and re-implanted in the caudate nucleus > of dopamine depleted primates, effectively survived and migrated," said Dr > Jean-Francoise Brunet of the Cell Transplantation Centre of Excellence for > Aging and Brain Repair who, along with colleagues, published their study in > Cell Transplantation. "The autologous, re-implanted cells survived at an > impressively high rate of 50 per cent for four months post-implantation." > > While the use of neural grafts to restore function after lesions or > degeneration of the central nervous system has been widely reported, the > objective of this study was to replace depleted neurons to a restricted > brain area and to avoid both the ethical controversies accompanying foetal > cell transplants as well as immune rejection. > > Researchers found that the cultured cells migrated, re-implanted into the > right caudate nucleus, and migrated through the corpus callosum to the > contralateral striatum. Most of the cells were found in the most dopamine > depleted region of the caudate nucleus. This study replicated in primates > the success the research team had previously reported using laboratory > mice. > > According to the researchers, the cultured cells exhibited neural > progenitor > characteristics that could make them useful for brain repair. > > "Our results confirm that adult brain cells can be obtained, cryopreserved > and kept in culture before being re-implanted in the donor where they > survive in vivo for at least four months," concluded Dr Brunet and > colleagues. The study has drawn considerable interest in the > transplantation > community. "This is an extremely important finding because although we have > known for many years that foetal cells can be used to replace damaged > neurons their limited availability has prevented widespread use in clinical > settings," commented Section Editor Dr John Sladek, professor of > paediatrics > and neuroscience at the University of Colorado School of Medicine. > > http://www.popularmechanics.co.za/content/news/singlepage.asp?key=877 > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn