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Stereotactic radiosurgery (SRS) offers a less invasive way to eliminate tremors 
caused by Parkinson's disease and essential tremor than deep brain stimulation 
(DBS) and radiofrequency (RF) treatments, and is as effective, according to a 
long-term study presented November 2, 2009, at the 51st Annual Meeting of the 
American Society for Radiation Oncology (ASTRO). 
"The study shows that radiosurgery is an effective and safe method of getting 
rid of tremors caused by Parkinson's disease and essential tremor, with 
outcomes that favorably compare to both DBS and RF in tremor relief and risk 
of complications at seven years after treatment," Rufus Mark, M.D., an author 
of the study and a radiation oncologist at the Joe Arrington Cancer Center and 
Texas Tech University, both in Lubbock, Texas said. "In view of these long-
term results, this non-invasive procedure should be considered a primary 
treatment option for tremors that are hard to treat." 
Parkinson's disease is a slowly progressive neurologic disease that causes 
tremors, in addition to other symptoms. Essential tremor is the most common of 
all movement disorders and causes uncontrollable shaking of the hands, head, 
and sometimes other parts of the body. 
Stereotactic radiation is a specialized type of external beam radiation 
therapy that pinpoints high doses of radiation directly on a confined area in a 
shorter amount of time than traditional radiation treatments. Stereotactic 
radiosurgery, or SRS, refers to a single or several stereotactic radiation 
treatments of the brain or spine. SRS is delivered by a team involving a 
radiation oncologist and a neurosurgeon. This radiation treatment is often 
called by the brand 
names of the manufacturers, including Axesse, CyberKnife, Gamma Knife, 
Novalis, Primatom, Synergy, X-Knife, TomoTherapy and Trilogy. 
Between 1991 and 2007, 183 patients underwent stereotactic radiosurgery 
thalamotomy, for hard-to-treat tremors caused by Parkinson's disease and 
essential tremors. A thalamotomy is a procedure that destroys tissue at a 
particular spot—the Ventralis Inter-Medius nucleus—on the thalamus of the 
brain which influences movement. 
With a median follow-up of seven years, 84 percent of patients had significant 
or complete resolution of tremors. In patients with Parkinson's disease, 83 
percent had near or complete tremor resolution, while those with essential 
tremor had 87 percent of this degree of tremor resolution. 
Source: American Society for Radiation Oncology

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