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Robert, has your father had a CAT scan or MRI to run out Normal Pressure 
Hydrocephalus?  This syndrome mimics Parkinson's disease but is caused by a 
build up of fluid in the brain - and is often misdiagnosed as PD.  The fact 
that your father suffered brain damage and that his symptoms have progressed 
rapidly makes me wonder if he has something other than PD.

The good news about NPH is that the symptoms can be easily reversed with the 
placement of a shunt.
------
God bless
Mary Ann (CG Jamie 68/28 with PD, died 11/20/07)

www.bentwillowfarm.org
>
> My name is Robert from Australia.
>
> My father received significant head injuries in a road accident in 2002.
>
> After rehabilitation he managed to slowly recover for a few years, but the 
> last
> 5 years he has developed all the cardinal symptoms of Parkinsons disease, 
> and
> over
> the last 6 months in particular these symptoms have progressed to such a 
> stage
> that my father's quality of life has seriously diminished.
>
> In 2005 we tried Sinimet but there was zero response.
>
> It seems, like most cases of atypical Parkinsons, that the dopa receptors 
> were
> not spared.
>
> I am desperately looking for treatments that may atleast modestly relive 
> some of
> my fathers symptoms. Even a 10% would make a huge difference for us.
>
> (1) In one weeks time we will see our doctor for botox injections. At this 
> stage
> I suspect that the injections will be in the calf muscles, but if anyone 
> can
> suggest sites of injection to assist with dystonia, I would really 
> appreciate
> it.
>
> (2) A week later we will be seeing a neurologist for trial of 
> pharmacological
> medications to hopefully assist. I know most neurologist would not even 
> bother,
> given the low response rate for atypical Parkinsons, but I have my fingers
> crossed.
>
> I have read of some success with atypical parkins and the Dopamine 
> receptor
> agonist called bromocriptine, and am hopeful that my father can trial 
> this.
>
> I have also read about the transdermal administration of rotigotine, and 
> would
> be asking about this too.
>
> I am however looking for any other pharmacological suggestions for 
> atypical
> parkinsons, with some science behind them, to suggest to the neurologist 
> as a
> trial.
>
> Can anyone help me?
>
> Thanks
>
> Robert
>
>
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