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Wow! This is not good news. Everyone thought that cell based therapies were going to be the answer to PD. I'm speechless. --------- Mary Ann www.bentwillowfarm.org > For years, cell-based therapies that involve the transplantation of > dopaminergic cells in to the brain have attracted considerable interest as > possible treatments for Parkinson's Disease. However, all of the > double-blind, > sham-controlled, studies have failed to meet their hoped for efficacy. > Transplantation of dopamine cells derived from the fetal mesencephalon is > also > associated with a potentially disabling form of dyskinesia that persists > even > after withdrawal of L-dopa. In addition, disability in advanced patients > primarily results from features that are not primarily due to insufficient > dopamine. These features are not adequately controlled with dopaminergic > therapies and are thus unable to respond to dopaminergic transplants. > Implanted dopaminergic neurons have also recently been found to contain > Lewy > bodies, which are signs of cell damage, suggesting that even after > transplantation they are dysfunctional and may have been affected by the > Parkinson's Disease process. Although stem cell therapies have been tried > in > Parkinson's Disease based on the claim that there is a massive loss of > dopamine producing cells in Parkinson's Disease, not a single study has > ever > shown this to be true. > > > viartis.net > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn