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. Seems to me to be a lot of postings of these articles without much thought as o why and where fore of the purpose. Whilst it's great to get the sources available as to the research that's going on one, must query the application of the research and the intent of the article. As I understand it transplantation of dopamine producing cells have no synaptic developmental history, and as such, best used only and a last resort dopamine supply, albeit uncontrolled. When approaching this reporting from the research point of view, one becomes rather bemused as to the claims that are being made in the attempt to attract research dollars. -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]] On Behalf Of mschild Sent: Thursday, November 26, 2009 10:39 AM To: [log in to unmask] Subject: DOPAMINERGIC TRANSPLANTS FAIL IN PARKINSON'S DISEASE Annals of Neurology [2009] 66 (5) : 591-596 (Olanow CW, Kordower JH, Lang AE, Obeso JA.) Complete abstract For years, cell-based therapies that involve the transplantation of dopaminergic cells in to the brain have attracted considerable interest as possible treatments for Parkinson's Disease. However, all of the double-blind, sham-controlled, studies have failed to meet their hoped for efficacy. Transplantation of dopamine cells derived from the fetal mesencephalon is also associated with a potentially disabling form of dyskinesia that persists even after withdrawal of L-dopa. In addition, disability in advanced patients primarily results from features that are not primarily due to insufficient dopamine. These features are not adequately controlled with dopaminergic therapies and are thus unable to respond to dopaminergic transplants. Implanted dopaminergic neurons have also recently been found to contain Lewy bodies, which are signs of cell damage, suggesting that even after transplantation they are dysfunctional and may have been affected by the Parkinson's Disease process. Although stem cell therapies have been tried in Parkinson's Disease based on the claim that there is a massive loss of dopamine producing cells in Parkinson's Disease, not a single study has ever shown this to be true. viartis.net ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn