 |
 |
My fathers symptoms are classic Parkinsons. I have a long list of his symptoms but I will not post unless it is of use in this thread. However I will state that his symptoms are identical to idiopathic PD, and he in fact has the whole range of symptoms, rather than just a subset.. Now his diagnosis one day in the future may be labelled differently, but for now PD+ is all we have to go on, given the 100% fit of symptoms. My father has tried Sinimet and Artane in the past, with no noticeable effect, but given that his symptoms have significantly progressed (especially his freezing, tremors & dystonia), it may be worthwhile to try again at higher doses. I made a reference to various dopamine receptor agonists because of the following that I have read with regard to non-idyopathic PD. ------- [0010] Dopamine receptor agonists are generally ineffective for the treatment of PPS (Mark, 2001, supra). In exceptional cases, there have been reports of a certain therapeutic success with individual dopamine agonists, although these effects appear to be substance-specific. For example, Wenning et al (Lancet, 2004, 3, 93) reported on the therapeutic success of bromocriptine in a trial with six patients, while a controlled trial with lisuride found no efficacy. Since it is known that the majority of dopamine agonists do not act on one sole dopamine receptor, but have a complex receptor profile (Newman-Tancredi, J Pharmacol Exp Ther 2002, 303, 805), the reason for the efficacy of bromocriptine could be the special features of the receptor profile or other not further characterised substance-specific properties. http://www.freshpatents.com/Use-of-rotigotine-for-treating-and-preventing-parkinson-s-plus-syndrome-dt20070816ptan20070191470.php ---------- -----Original Message----- From: mschild <[log in to unmask]> To: [log in to unmask] Sent: Fri, Nov 27, 2009 8:16 pm Subject: Re: Treatments for atypical Parkinsons > My name is Robert from Australia. > > My father received significant head injuries in a road accident in 2002. > > After rehabilitation he managed to slowly recover for a few years, but the > last 5 years he has developed all the cardinal symptoms of Parkinsons > disease, and over > the last 6 months in particular these symptoms have progressed to such a > stage that my father's quality of life has seriously diminished. what drugs is your father on? what are his symptoms? Head injuries can produce parkinsonism but he can also develop something not related to head injuries. Response to ldopa is a sign of idiopathic PD but usually if there is no respnose to ldopa, agonists don´t help much either. Still, there are bizarre responses known so I hope the neurologist will find the right drug to help your father maryse ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn