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I have reservations about the use of any mood enhancement therapies that are taken with PD medication. For starters the CBD (I assume your talking about the active ingredient of THC in cannabis) is unproven as anything bar a mood improver. Personally I would put this drug in the same category as alcohol a far as a “well being type effect” is concerned. The problem is that the side effects of alcohol are very real when it comes to nervous system depression. I mean that in the sense of inhibition of the nervous system not in the clinical depression category. As far as THC is concerned there’s a wide variety of opinion based research, due to the categorical placement by the FDA in its ATF approach to this drugs use. However that’s another story. My main reason for not using THC is that the wrong impression is being prompted as far as attitude towards mood enhancing medication is concerned i.e. Take another pill this will help. John thomas -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]] On Behalf Of mschild Sent: Sunday, November 29, 2009 9:40 AM To: [log in to unmask] Subject: Cannabidiol for the treatment of psychosis in Parkinson’sdisease The management of psychosis in Parkinson’s disease (PD) has been considered a great challenge for clinicians and there is a need for new pharmacological intervention. Previously an antipsychotic and neuroprotective effect of Cannabidiol (CBD) has been suggested. Therefore, the aim of the present study was to directly evaluate for the first time, the efficacy, tolerability and safety of CBD on PD patients with psychotic symptoms. This was an open-label pilot study. Six consecutive outpatients (four men and two women) with the diagnosis of PD and who had psychosis for at least 3 months were selected for the study. All patients received CBD in flexible dose (started with an oral dose of 150 mg/day) for 4 weeks, in addition to their usual therapy. The psychotic symptoms evaluated by the Brief Psychiatric Rating Scale and the Parkinson Psychosis Questionnaire showed a significant decrease under CBD treatment. CBD did not worsen the motor function and decreased the total scores of the Unified Parkinson’s Disease Rating Scale. No adverse effect was observed during the treatment. These preliminary data suggest that CBD may be effective, safe and well tolerated for the treatment of the psychosis in PD. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn