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http://www.ualberta.ca/~csps/JPPS2(2)/D.Brocks2/anticholinergic.htm this link whilst not advocating the use certainly classifies the abuse to coin a phrase :) it goes along with [log in to unmask] Of Ontario's comment on so called doctors and PD -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]] On Behalf Of Kathleen Cochran Sent: Sunday, December 20, 2009 5:42 AM To: [log in to unmask] Subject: Re: Falls in PD Correlate with Cholinergic, not Dopaminergic, Dysfunction This is the first I have ever heard of anticholinergics for PD. Is there anyone who can say more about these drugs and their experiences with them? Kathleen 2009/12/19 Steve Rack <[log in to unmask]> > Hmm so whats new :) >> > > The only drug I take for PD so far (5 years) is benztropine, an > anticholinergic. I lose my balance sometimes when people hug me but I've > never actually fallen. > > > >> -----Original Message----- >> From: Parkinson's Information Exchange Network >> [mailto:[log in to unmask]] On Behalf Of mschild >> Sent: Thursday, December 17, 2009 10:00 AM >> To: [log in to unmask] >> Subject: Falls in PD Correlate with Cholinergic, not Dopaminergic, >> Dysfunction >> >> >> >> Loss of cholinergic function predicts falling in Parkinson's disease, >> according to a new study, independent of dopaminergic denervation. >> >> Seventeen PD patients with a history of falls, 27 PD patients without such >> history, and 15 controls underwent radioimaging with tracers for >> cholinergic >> >> and dopaminergic activity. Both PD groups had reduced dopaminergic >> function >> compared to controls, but were not significantly different from each >> other. >> Compared to controls, combined cortical and thalamic cholinergic function >> was >> reduced in PD non-fallers (-6.6%) and was even worse in fallers (-12.3%). >> The >> same pattern held true for cortical function alone. In contrast, thalamic >> cholinergic function was reduced compared to controls only in fallers. >> >> "Thalamic acetylcholinesterase activity derives mainly from terminals of >> brainstem pedunculopontine nucleus neurons that play a role in the >> generation >> of movement," the authors state, "and loss of AChE is likely to reflect >> PPN >> neuron dysfunction or degeneration. Our results are consistent with a key >> role >> for the PPN in the maintenance of balance in humans and with PPN >> dysfunction/degeneration as a cause of impaired postural control and gait >> in >> >> PD." They suggest that cholinergic therapy may have a role to play in >> treatment of gait disorder in PD, but "it is uncertain whether the current >> generation of cholinesterase inhibitors have sufficient brain penetrance >> to >> produce meaningful clinical benefits." >> >> History of falls in Parkinson disease is associated with reduced >> cholinergic >> >> activity >> NI Bohnen, MLTM Muller, RA Koeppe, SA studenski, MA Kilbourn, KA Frey, RL >> Albin >> Neurology 2009;73:1670-1676 >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: mailto: >> [log in to unmask] >> In the body of the message put: signoff parkinsn >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: mailto: >> [log in to unmask] >> In the body of the message put: signoff parkinsn >> > > > -- > Steve in VT > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn