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Yikes! Sounds like scary stuff. Kathleen 2009/12/21 <[log in to unmask]> > Kathleen, I had a terrible experience on Artane. Had my first > hallucination at the end of the first week on it. When I titrated, my > mouth got so > dry I had to hold water in my mouth as long as I could. I was coughing up > a > storm and very hoarse. Went to my primary care doc and he thought I might > have strep but the culture was negative. He told me the Artane would just > have to work it's way out of my system. > > Roberta Innarella > > "Real life isn't always going to be perfect or go our way, but the > recurring acknowledgement of what is working in our lives can help us not > only to > survive but surmount our difficulties." Sara Ban Breathnach > > > In a message dated 12/21/2009 2:00:26 A.M. Eastern Standard Time, > [log in to unmask] writes: > > This is the first I have ever heard of anticholinergics for PD. Is there > anyone who can say more about these drugs and their experiences with > them? > > Kathleen > > 2009/12/19 Steve Rack <[log in to unmask]> > > > Hmm so whats new :) > >> > > > > The only drug I take for PD so far (5 years) is benztropine, an > > anticholinergic. I lose my balance sometimes when people hug me but I've > > never actually fallen. > > > > > > > >> -----Original Message----- > >> From: Parkinson's Information Exchange Network > >> [mailto:[log in to unmask]] On Behalf Of mschild > >> Sent: Thursday, December 17, 2009 10:00 AM > >> To: [log in to unmask] > >> Subject: Falls in PD Correlate with Cholinergic, not Dopaminergic, > >> Dysfunction > >> > >> > >> > >> Loss of cholinergic function predicts falling in Parkinson's disease, > >> according to a new study, independent of dopaminergic denervation. > >> > >> Seventeen PD patients with a history of falls, 27 PD patients without > such > >> history, and 15 controls underwent radioimaging with tracers for > >> cholinergic > >> > >> and dopaminergic activity. Both PD groups had reduced dopaminergic > >> function > >> compared to controls, but were not significantly different from each > >> other. > >> Compared to controls, combined cortical and thalamic cholinergic > function > >> was > >> reduced in PD non-fallers (-6.6%) and was even worse in fallers > (-12.3%). > >> The > >> same pattern held true for cortical function alone. In contrast, > thalamic > >> cholinergic function was reduced compared to controls only in fallers. > >> > >> "Thalamic acetylcholinesterase activity derives mainly from terminals > of > >> brainstem pedunculopontine nucleus neurons that play a role in the > >> generation > >> of movement," the authors state, "and loss of AChE is likely to reflect > >> PPN > >> neuron dysfunction or degeneration. Our results are consistent with a > key > >> role > >> for the PPN in the maintenance of balance in humans and with PPN > >> dysfunction/degeneration as a cause of impaired postural control and > gait > >> in > >> > >> PD." They suggest that cholinergic therapy may have a role to play in > >> treatment of gait disorder in PD, but "it is uncertain whether the > current > >> generation of cholinesterase inhibitors have sufficient brain > penetrance > >> to > >> produce meaningful clinical benefits." > >> > >> History of falls in Parkinson disease is associated with reduced > >> cholinergic > >> > >> activity > >> NI Bohnen, MLTM Muller, RA Koeppe, SA studenski, MA Kilbourn, KA Frey, > RL > >> Albin > >> Neurology 2009;73:1670-1676 > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: mailto: > >> [log in to unmask] > >> In the body of the message put: signoff parkinsn > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: mailto: > >> [log in to unmask] > >> In the body of the message put: signoff parkinsn > >> > > > > > > -- > > Steve in VT > > > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto: > > [log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > ca > In the body of the message put: signoff parkinsn > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn