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Kathleen, I had a terrible experience on Artane. Had my first hallucination at the end of the first week on it. When I titrated, my mouth got so dry I had to hold water in my mouth as long as I could. I was coughing up a storm and very hoarse. Went to my primary care doc and he thought I might have strep but the culture was negative. He told me the Artane would just have to work it's way out of my system. Roberta Innarella "Real life isn't always going to be perfect or go our way, but the recurring acknowledgement of what is working in our lives can help us not only to survive but surmount our difficulties." Sara Ban Breathnach In a message dated 12/21/2009 2:00:26 A.M. Eastern Standard Time, [log in to unmask] writes: This is the first I have ever heard of anticholinergics for PD. Is there anyone who can say more about these drugs and their experiences with them? Kathleen 2009/12/19 Steve Rack <[log in to unmask]> > Hmm so whats new :) >> > > The only drug I take for PD so far (5 years) is benztropine, an > anticholinergic. I lose my balance sometimes when people hug me but I've > never actually fallen. > > > >> -----Original Message----- >> From: Parkinson's Information Exchange Network >> [mailto:[log in to unmask]] On Behalf Of mschild >> Sent: Thursday, December 17, 2009 10:00 AM >> To: [log in to unmask] >> Subject: Falls in PD Correlate with Cholinergic, not Dopaminergic, >> Dysfunction >> >> >> >> Loss of cholinergic function predicts falling in Parkinson's disease, >> according to a new study, independent of dopaminergic denervation. >> >> Seventeen PD patients with a history of falls, 27 PD patients without such >> history, and 15 controls underwent radioimaging with tracers for >> cholinergic >> >> and dopaminergic activity. Both PD groups had reduced dopaminergic >> function >> compared to controls, but were not significantly different from each >> other. >> Compared to controls, combined cortical and thalamic cholinergic function >> was >> reduced in PD non-fallers (-6.6%) and was even worse in fallers (-12.3%). >> The >> same pattern held true for cortical function alone. In contrast, thalamic >> cholinergic function was reduced compared to controls only in fallers. >> >> "Thalamic acetylcholinesterase activity derives mainly from terminals of >> brainstem pedunculopontine nucleus neurons that play a role in the >> generation >> of movement," the authors state, "and loss of AChE is likely to reflect >> PPN >> neuron dysfunction or degeneration. Our results are consistent with a key >> role >> for the PPN in the maintenance of balance in humans and with PPN >> dysfunction/degeneration as a cause of impaired postural control and gait >> in >> >> PD." They suggest that cholinergic therapy may have a role to play in >> treatment of gait disorder in PD, but "it is uncertain whether the current >> generation of cholinesterase inhibitors have sufficient brain penetrance >> to >> produce meaningful clinical benefits." >> >> History of falls in Parkinson disease is associated with reduced >> cholinergic >> >> activity >> NI Bohnen, MLTM Muller, RA Koeppe, SA studenski, MA Kilbourn, KA Frey, RL >> Albin >> Neurology 2009;73:1670-1676 >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: mailto: >> [log in to unmask] >> In the body of the message put: signoff parkinsn >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: mailto: >> [log in to unmask] >> In the body of the message put: signoff parkinsn >> > > > -- > Steve in VT > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] ca In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn