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This post caught my attention. My father is 76 years old, and he suffers from atypical Parkinsonism, whereby he is unresponsive to Sinemet. Of growing concern however has been his cognitive decline, which has been very noticeable of late. While looking into dementia medications, I came across the Cholinergic group, which are indicated for dementia in Australia. Does this suggest that the Cholinergic group may be helpful both for PD symptoms and for cognitive decline? Robert -----Original Message----- From: Kathleen Cochran <[log in to unmask]> To: [log in to unmask] Sent: Thu, Dec 24, 2009 1:34 am Subject: Re: Falls in PD Correlate with Cholinergic, not Dopaminergic, Dysfunction This is very interesting. I wonder how the variability of PD's symptoms andprogression relates to individual differences in the balance of dopamine andacetylcholine (and other neurotransmitters as well).Kathleen2009/12/22 Steve Rack <[log in to unmask]>> > This is the first I have ever heard of anticholinergics for PD.>>>>>> anticholinergic are not recommended for PD. They advocate the contrary,>> cholinergic therapy>>> maryse>> My neurologist put me on benztropine (anticholinergic) several years ago. I> had tried sinement for a few weeks and it didn't seem to work. He says it> partially restores the balance between dopamine and acytel choline. It seems> to affect the amplitude of my tremor rather than the frequency. If I miss a> dose my body lets me know within hours.> --> Steve in VT>>> ----------------------------------------------------------------------> To sign-off Parkinsn send a message to: mailto:> [log in to unmask]> In the body of the message put: signoff parkinsn>----------------------------------------------------------------------To sign-off Parkinsn send a message to: mailto:[log in to unmask] the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn