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What, you find THIS confusing? "Upregulation of PDXK in dopaminergic neurons may be explained by an adaptive mechanism to increase dopamine metabolism in the remaining funcitonal dopaminergic neurons of the SNc or to levodopa therapy." As I was just saying to my wife, "upregulation of adaptive mechanism" is one of the problems with our economy. ????? :-) John ----- Original Message ----- From: "Nic Marais" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, February 18, 2010 2:35 AM Subject: Re: Vitamin B6 Gene Implicated in PD > Can someone translate this for me please... Does B6 help to cause PD, > or does it help to prevent it? > > (Dementia kicking in?) > > > Nic 57/16 > > On 18 February 2010 11:52, mschild <[log in to unmask]> wrote: >> A variant in a gene that converts vitamin B6 to a cofactor for dopamine >> synthesis is implicated in some cases of Parkinson's disease, according >> to a >> new study. >> >> The study used gene expression profiling (i.e., determining changes in >> messenger RNA production) to identify candidate genes, and then >> determined >> whether variants in those genes were associated with disease, a process >> called >> "genomic convergence." The value of such a study design is that it can >> detect >> associations weaker than those currently found through genome-wide >> association >> studies. >> >> The authors performed whole-genome expression profiling in 100 individual >> substantia nigra cells from a single individual from a brain bank PD >> case. >> After Bonferroni correction and confirmation by real-time expression >> analysis, >> several genes were identified as significantly altered between PD and >> control >> cells. Variants of one, PDXK (pyridoxal kinase), were found to be >> associated >> with PD in three European cohorts. >> >> "PDXK catalyzes the conversion of vitamin B6 (pyridoxine, pyridoxal, and >> pyridoxamine) to pyridoxal 5'-phosphate (PLP)," the authors state. PLP is >> thought to be a cofactor in multiple reactions, including the >> biosynthesis of >> dopamine by dopa decarboxylase. >> >> "Upregulation of PDXK in dopaminergic neurons may be explained by an >> adaptive >> mechanism to increase dopamine metabolism in the remaining funcitonal >> dopaminergic neurons of the SNc or to levodopa therapy." The authors >> speculate >> that the polymorphism associated with PD may influence enzyme amount or >> activity. Dietary vitamin B6 has previously been linked to a reduced risk >> of >> PD in smokers. >> >> Single-cell expression profiling ofdopaminergic neurons combined with >> association analysis identifies pyridoxal kinase as Parkinson's disease >> gene >> M Elstner, CM Morris, K Heim, et al. >> Ann Neurol 2009;66:792-798 >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn