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Can someone translate this for me please... Does B6 help to cause PD, or does it help to prevent it? (Dementia kicking in?) Nic 57/16 On 18 February 2010 11:52, mschild <[log in to unmask]> wrote: > A variant in a gene that converts vitamin B6 to a cofactor for dopamine > synthesis is implicated in some cases of Parkinson's disease, according to a > new study. > > The study used gene expression profiling (i.e., determining changes in > messenger RNA production) to identify candidate genes, and then determined > whether variants in those genes were associated with disease, a process called > "genomic convergence." The value of such a study design is that it can detect > associations weaker than those currently found through genome-wide association > studies. > > The authors performed whole-genome expression profiling in 100 individual > substantia nigra cells from a single individual from a brain bank PD case. > After Bonferroni correction and confirmation by real-time expression analysis, > several genes were identified as significantly altered between PD and control > cells. Variants of one, PDXK (pyridoxal kinase), were found to be associated > with PD in three European cohorts. > > "PDXK catalyzes the conversion of vitamin B6 (pyridoxine, pyridoxal, and > pyridoxamine) to pyridoxal 5'-phosphate (PLP)," the authors state. PLP is > thought to be a cofactor in multiple reactions, including the biosynthesis of > dopamine by dopa decarboxylase. > > "Upregulation of PDXK in dopaminergic neurons may be explained by an adaptive > mechanism to increase dopamine metabolism in the remaining funcitonal > dopaminergic neurons of the SNc or to levodopa therapy." The authors speculate > that the polymorphism associated with PD may influence enzyme amount or > activity. Dietary vitamin B6 has previously been linked to a reduced risk of > PD in smokers. > > Single-cell expression profiling ofdopaminergic neurons combined with > association analysis identifies pyridoxal kinase as Parkinson's disease gene > M Elstner, CM Morris, K Heim, et al. > Ann Neurol 2009;66:792-798 > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn