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Thanks Ray! Nic 56/16 On 18 February 2010 20:35, rayilynlee <[log in to unmask]> wrote: > I interpreted it that there is a gene variant that is implicated in causing > PD. I added B6 to my supplements, having read elsewhere it was a good B > vitamin. > > Ray > Rayilyn Brown > Past Director AZNPF > Arizona Chapter National Parkinson Foundation > > > -------------------------------------------------- > From: "Nic Marais" <[log in to unmask]> > Sent: Thursday, February 18, 2010 3:35 AM > To: <[log in to unmask]> > Subject: Re: Vitamin B6 Gene Implicated in PD > >> Can someone translate this for me please... Does B6 help to cause PD, >> or does it help to prevent it? >> >> (Dementia kicking in?) >> >> >> Nic 57/16 >> >> On 18 February 2010 11:52, mschild <[log in to unmask]> wrote: >>> >>> A variant in a gene that converts vitamin B6 to a cofactor for dopamine >>> synthesis is implicated in some cases of Parkinson's disease, according >>> to a >>> new study. >>> >>> The study used gene expression profiling (i.e., determining changes in >>> messenger RNA production) to identify candidate genes, and then >>> determined >>> whether variants in those genes were associated with disease, a process >>> called >>> "genomic convergence." The value of such a study design is that it can >>> detect >>> associations weaker than those currently found through genome-wide >>> association >>> studies. >>> >>> The authors performed whole-genome expression profiling in 100 individual >>> substantia nigra cells from a single individual from a brain bank PD >>> case. >>> After Bonferroni correction and confirmation by real-time expression >>> analysis, >>> several genes were identified as significantly altered between PD and >>> control >>> cells. Variants of one, PDXK (pyridoxal kinase), were found to be >>> associated >>> with PD in three European cohorts. >>> >>> "PDXK catalyzes the conversion of vitamin B6 (pyridoxine, pyridoxal, and >>> pyridoxamine) to pyridoxal 5'-phosphate (PLP)," the authors state. PLP is >>> thought to be a cofactor in multiple reactions, including the >>> biosynthesis of >>> dopamine by dopa decarboxylase. >>> >>> "Upregulation of PDXK in dopaminergic neurons may be explained by an >>> adaptive >>> mechanism to increase dopamine metabolism in the remaining funcitonal >>> dopaminergic neurons of the SNc or to levodopa therapy." The authors >>> speculate >>> that the polymorphism associated with PD may influence enzyme amount or >>> activity. Dietary vitamin B6 has previously been linked to a reduced risk >>> of >>> PD in smokers. >>> >>> Single-cell expression profiling ofdopaminergic neurons combined with >>> association analysis identifies pyridoxal kinase as Parkinson's disease >>> gene >>> M Elstner, CM Morris, K Heim, et al. >>> Ann Neurol 2009;66:792-798 >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: >>> mailto:[log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn