 |
 |
Thanks! Now I don't feel so stupid anymore;-) Nic 57/16 On 18 February 2010 18:31, kbachn <[log in to unmask]> wrote: > you need a PHD in biochem to understand what is being said here .....LOL > > > ----- Original Message ----- From: "mschild" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Thursday, February 18, 2010 4:52 AM > Subject: Vitamin B6 Gene Implicated in PD > > >> A variant in a gene that converts vitamin B6 to a cofactor for dopamine >> synthesis is implicated in some cases of Parkinson's disease, according to >> a >> new study. >> >> The study used gene expression profiling (i.e., determining changes in >> messenger RNA production) to identify candidate genes, and then determined >> whether variants in those genes were associated with disease, a process >> called >> "genomic convergence." The value of such a study design is that it can >> detect >> associations weaker than those currently found through genome-wide >> association >> studies. >> >> The authors performed whole-genome expression profiling in 100 individual >> substantia nigra cells from a single individual from a brain bank PD case. >> After Bonferroni correction and confirmation by real-time expression >> analysis, >> several genes were identified as significantly altered between PD and >> control >> cells. Variants of one, PDXK (pyridoxal kinase), were found to be >> associated >> with PD in three European cohorts. >> >> "PDXK catalyzes the conversion of vitamin B6 (pyridoxine, pyridoxal, and >> pyridoxamine) to pyridoxal 5'-phosphate (PLP)," the authors state. PLP is >> thought to be a cofactor in multiple reactions, including the biosynthesis >> of >> dopamine by dopa decarboxylase. >> >> "Upregulation of PDXK in dopaminergic neurons may be explained by an >> adaptive >> mechanism to increase dopamine metabolism in the remaining funcitonal >> dopaminergic neurons of the SNc or to levodopa therapy." The authors >> speculate >> that the polymorphism associated with PD may influence enzyme amount or >> activity. Dietary vitamin B6 has previously been linked to a reduced risk >> of >> PD in smokers. >> >> Single-cell expression profiling ofdopaminergic neurons combined with >> association analysis identifies pyridoxal kinase as Parkinson's disease >> gene >> M Elstner, CM Morris, K Heim, et al. >> Ann Neurol 2009;66:792-798 >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn