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Rick McGirr, age 56, diagnosis 2001. In battling my overwhelming fatigue, I have made many changes to my medications, deleting drugs that increase sleepiness and tiredness, and trying new ones to see if there is any improvement. After Mirapex, Requip, Selegiline, Zelapar, (I'm probably forgetting a few) I'm adding Provigil to my list of ineffective medications. Most recently, My neurologist prescribed Provigil, a controlled substance, to see if I could have any more energy than I had been having. First, I had to wean myself off of Zelepar due to potentially serious to fatal interactions, which I discovered by reading the bottle and the info sheet. Then took a low dose of Provigil to no noticeable effect. In cooperation with my neurologist, I doubled the dose and took it for several months, again, to no noticeable effect. Provigil did not alter my moods, energy level, or sleep patterns. So I have recently concluded the backward process of weaning back off of Provigil, and finally, with no noticeable effect. So now it's Sinemet and Stalevo, along with an antidepressant every morning. Soon the list of tried and rejected meds will be as long as my arm. After revisiting the 1975 bestseller, "The Relaxation Response", by Herbert Benson, MD, I'm going to do more reading on alternative approaches to managing PD. I really appreciate this listserv for its basic attitude of not jumping to conclusions (which seems to go along quite nicely with living in Buffalo, NY!), and also for its great info on all that goes on in the PD world. I haven't written much lately, but I know that you probably understand. Thanks all! ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn