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it is good news that these earlier studies are being reanalyzed. We may find some of the trial "failures" were actually not failures after all. i'm glad its also being recognized that some of the PWP in these trials did in fact get better, and that should be considered a success, even if the statistical endpoints were not met.


see:
http://cordis.europa.eu/wire/index.cfm?fuseaction=article.Detail&rcn=22249&rev=0

Roger Barker
Brain Repair Centr
Forvie Site, Robinson Way
CB2 0PY Cambridge
United Kingdom
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Tel: 0041446353382
Fax: 0041446353385
http://www.brc.cam.ac.uk

We are proud to announce the official start of TRANSEURO, Europe's premiere clinical study on the treatment of Parkinson's Disease (PD) patients using a cell therapy approach.
There are currently no cures for PD but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for years, whilst others have shown no or only modest clinical improvements, and in some cases also developed severe, off-state graft-induced dyskinesias (GIDs).

There is therefore an urgent need to revisit the trials that have already been done with fetal VM tissue in PD patients, with the expectation that a critical reassessment can form the basis for an optimized and more standardized procedure that will translate into more consistently efficacious transplants with minimal side-effects.

TRANSEURO is coordinated by Dr. Roger Barker from the Cambridge University and is gathering a group of international experts, including the key investigators of the previous European and North American trials, who will join forces in a new round of experimental work and cell therapy trials in PD. They will jointly develop new protocols where all previously-tested factors are taken into account.

TRANSEURO is a 5-year Collaborative Project supported through the FP7 European Commission Health programme, contract number 242003.
Remarks :

Contact: Dr. Roger Barker – [log in to unmask]
Subject: Seventh Framework Programme;
Country: Austria; France; Germany; Sweden; United Kingdom;
Institution: Medium Company; Private Research; Public Research; Small Company;
Category: Press Alert;
Programme Acronyms: FP7-HEALTH; 



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