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Wait a minute...recruitment is currently under way for a Ceregene clinical
trial to be conducted at a number of sites.

From Movement Disorder News, the newsletter of the Beth Israel Parkinson's
Disease and Movement Disorders Research Center (Fall 2010, Issue No. 2):

"...CERE-120 has been shown to be safe in animals and in people with PT, and
it has been shown to protect and improve the function of damaged brain
cells. CERE-120 has the potential to improve PD symptoms and possibly slow
disease progression."

There is nothing about this that says "failure" to me.

And about the so-called failure of GDNF: well...

Kathleen



Clinical Drug Trials: Growth Factor and Parkinson's Disease

On 27 October 2010 13:51, mschild <[log in to unmask]> wrote:

>  NEURTURIN FAILS CLINICAL TRIALS FOR PARKINSON'S DISEASE
>
> Lancet Neurology [2010] Oct 20 [Epub ahead of print] (Marks WJ Jr, Bartus
> RT,
> Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D,
> Verhagen
> L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman
> R,
> Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K,
> Kordower JH, Olanow CW.) Complete abstract
>
> Neurturin was hailed by its sponsors Ceregene and the Michael J Fox
> Foundation
> as having great potential in the treatment of Parkinson's Disease, but has
> been found to be completely ineffective. Neurturin (CERE-120) is an
> experimental drug that contains the human gene for a growth factor called
> neurturin. It is used to deliver the neurturin gene by surgical means,
> directly into the brain of people with Parkinson's Disease. It was found to
> be
> worse than doing nothing, as it was as ineffective as sham surgery (doing
> nothing) yet still caused severe adverse events in a third of the patients.
> Neurturin is the same type of treatment as GDNF reference. GDNF was also
> previously hailed as a great breakthrough in the treatment of Parkinson's
> Disease. Yet all major clinical trials of GDNF and Neurturin have failed.
>
>
> www.viartis.net
>
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