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It's reduced researcher's inhibitions against repeting themselves. Quoting Nic Marais <[log in to unmask]>: > How many more times are they going to 'discover' this? > > Nic 58/16 > selev > On 11 November 2010 21:44, mschild <[log in to unmask]> wrote: > > > > > > Dopamine agonist stimulation reduces activity in brain networks linked to > > impulse control and response inhibition, according to a new study. In PD > non- > > gamblers, activity in these areas increased in response to the same > > stimulation. > > > > PET imaging was performed before and after apomorphine administration in 14 > PD > > patients, 7 with DA-induced pathological gambling, and 7 without. During > each > > imaging session, the patient engaged in a simple card choice test, which > > rewarded a correct choice with a visual display indicating the correct > choice > > had been made. > > > > The effect of DA administration was opposite in the two groups. In non- > > gamblers, administration of apomorphine "significantly increased activity" > in > > the left lateral orbitofrontal cortex (OFC), right rostral cingulate zone > > (RCZ), right amygdala, and left ventral anterior external pallidum (GPe), > > "while gamblers showed a significant DA-induced reduction of neuronal > activity > > in these regions." In gamblers, the decrease in activity correlated with > an > > increase in gambling symptoms following DA administration, as determined by > a > > symptom questionnaire. > > > > "Hypoactivity of the lateral OFC has previously been reported in drug > > addiction and pathological gambling in non-PD subjects," the authors note, > > "and is thought to play a crucial role in assigning subjective value to > > actions by encoding and updating expectations of future rewards or > > punishments....The RCZ is thought to be engaged in monitoring functions > that > > are involved in preventing negative consequences." > > > > They conclude, "We propose that in vulnerable patients with PD, DAs produce > an > > abnormal neuronal pattern that resembles those found in nonparkinsonian > > pathological gambling and drug addiction." > > > > Drug-induced deactivation of inhibitory networks predicts pathological > > gambling in PD > > T van Eimeren, G Pellechia, R Cilia, B Ballanger, TDL Steeves, S Houle, JM > > Miyasaki, M Zurowski, AE Lang, AP Strafella > > Neurology 2010;75:1711-1716 > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------- This mail sent through http://www.ukonline.net ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn