Hi Ray, My dad had DBS a week ago but his dyskenisia has increased significantly. Did u experience the same? Interesting comment on botox I need to research this thanks! Rose Sent via my BlackBerry from Vodacom - let your email find you! -----Original Message----- From: Rayilyn Brown <[log in to unmask]> Sender: Parkinson's Information Exchange Network <[log in to unmask]> Date: Wed, 1 Dec 2010 10:44:53 To: <[log in to unmask]> Reply-To: Parkinson's Information Exchange Network <[log in to unmask]> Subject: Re: Solo Sinemet Karol I don't take Sinemet at all. I had DBS in 2003 and that stopped the tremors. Sinemet only helped on the first dose. I've tried it many times. Took it when batteries died this summer so I could move a little, but doesn't seem to help at all now that my batteries have been replaced. DBS is great for tremor; doesn't help all that much for balance, bradykinesia, micrographia and makes voice worse, but its worth it to me. I had botox recently for leg dystonia but it doesn't seem to have helped. Some people with PD find botox helpful for dystonia. Ray From: Karol Klim Sent: Wednesday, December 01, 2010 3:55 AM To: [log in to unmask] Subject: Solo Sinemet Hello, I am 53 years of age and have been recently diagnosed with PD and am taking .75 of Sinemet and .75 of Mirapex. I would like to see how I would do with just taking Sinemet alone. I am concerned about the side effects of Mirapex, particularly the "sudden onset of sleep" possibility while driving. It sounds like you have had a lot of success with only taking Sinemet at a very low dosage. Is this true or have you had some tremors and rigidity? I would like to do the same, if possible. thanks for your help. Karol ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn