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What an incredibly negative summary: "only" this, "only" that. I would happily undergo a treatment that would lead to a 23 percent reduction in symptoms. It really wouldn't matter to me how much of that were attributable to the surgical method. Kathleen On 19 March 2011 02:19, mschild <[log in to unmask]> wrote: > The Lancet Neurology, Early Online Publication, 17 March 2011 (P.A.LeWitt, > A.R.Rezai, M.A.Leehey, S.G. Ojemann, A.W.Flaherty, E.N.Eskandar, > S.K.Kostyk, > K.Thomas, A.Sarkar, M.S.Siddiqui, S.B.Tatter, J.M.Schwalb, K.L.Poston, > J.M.Henderson, R.M.Kurlan, I. H.Richard, L.Van Meter, C.V.Sapan, > M.J.During, > M.G.Kaplitt, A. Feigin) Complete abstract > > A surgical method of increasing the levels of GABA, which is a substance > involved in muscular movement, has resulted in claims of the method being > beneficial for Parkinson's Disease. AAV2-GAD, which is called NLX-P101, was > delivered in to the subthalamic nucleus of the brains of people with > Parkinson's Disease. GAD is the enzyme (a chemical substance) that makes > GABA > naturally in the brain. Only a third of the elligible patients were given > the > treatment. A third of those elligible had to be excluded because of > technical > problems. The other third of those elligible only received sham surgery (no > treatment at all). > > There was a 23% reduction in symptoms in the third of patients that were > treated. However, even those that were not treated at all reduced their > symptoms by nearly 13%. So the actual benefit of the surgical method used > was > only a 10% reduction in symptoms in those that were treated. Of the adverse > events experienced, the most common were headache and nausea. The study was > carried out for only six months. It is normal for any artificial > stimulation of > a biochemical function, as occurred in this study, to eventually start > reversing due to a process called feedback inhibition. For more current > news > go to Parkinson's Disease News. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn