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15th May 2011 - New research

RETINAL STEM CELLS FAIL TO RID PARKINSON'S DISEASE

Lancet Neurology [2011] May 10 [Epub ahead of print] (Gross RE, Watts RL, 
Hauser RA, Bakay RA, Reichmann H, von Kummer R, Ondo WG, Reissig E, Eisner W, 
Steiner-Schulze H, Siedentop H, Fichte K, Hong W, Cornfeldt M, Beebe K, 
Sandbrink R) Complete abstract

Human retinal pigment epithelial (RPE) cells in the eyes also produce L-dopa. 
So their transplantation into the brain of people with Parkinson's Disease was 
considered to be able to improve the continuity of the administration of L-
dopa better than the use of oral L-dopa. Researchers aimed to assess the 
safety, tolerability, and efficacy of transplantation of human retinal pigment 
epithelial cells into people with advanced Parkinson's Disease. Around 650,000 
cells were injected in to the brain of each patient.  Each person's symptoms 
were then assessed after a year.

However, it was found that the treatment made no difference at all concerning 
their Parkinson's Disease symptoms. The method also caused adverse events, 
most of which were neurological or psychiatric. The authors of the research 
concluded that transplantation of human retinal pigment epithelial cells 
provided no benefit for Parkinson's Disease. A previous study found that the 
transplanted retinal cells simply failed to survive. For more information go 
to Retinal stem cells disappear after surgery. 

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