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Any FDA approved drug label can be found using the PIENO search box at the bottom of the page at: <http://www.parkinsons-information-exchange-network-online.com/archiveindex/>http://www.parkinsons-information-exchange-network-online.com/archiveindex/ http://tinyurl.com/azilectFDAlabel > >Information for Patients > > > >Patients and caregivers should be informed about which foods and >beverages to avoid because of high tyramine content.They should be >informed that a hypertensive crisis could occur after ingestion of >certain foods (e.g., aged cheeses, pickled herring, yeast extract) >or beverages (e.g., some red wines and certain beers) containing >significant amounts of tyramine, or amines contained in some >medications including some over-the-counter cough/cold medications. >Foods high in tyramine content include those that have undergone >protein change by aging, fermentation, pickling, or smoking to >improve flavor such as aged cheeses, air-dried meats, sauerkraut, >soy sauce, tap/draft beers and red wines. The tyramine content of >any protein-rich food may be increased if stored for long periods or >improperly refrigerated. > >Patients and caregivers should be informed of the signs and symptoms >associated with hypertensive crisis, including severe headache, >blurred vision, difficulty thinking, seizures, chest pain, >unexplained nausea or vomiting, or signs or symptoms of a >stroke. Patients and caregivers should seek immediate medical >attention for patients who develop any severe headache or other >atypical or unusual symptoms not previously experienced. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A54FBD8C-670C-4E03-BAC2-71BF546F37AF>WARNINGS). > >Patients should inform their physician if they are taking, or >planning to take, any prescription or over-the-counter drugs, >especially antidepressants and over-the-counter cold medications, >since there is a potential for interaction with AZILECT. Patients >should not use meperidine with AZILECT. > >Patients taking AZILECT as adjunct to levodopa should be advised >there is the possibility of increased dyskinesia and postural hypotension. > >Patients are advised to monitor for melanomas frequently and on a >regular basis. Ideally, periodic skin examinations should be >performed by appropriately qualified individuals (e.g., dermatologists). > >Patients should be instructed to take AZILECT as prescribed. If a >dose is missed, the patient should not double-up the dose of >AZILECT. The next dose should be taken at the usual time on the following day. > > > >Drug Interactions > > > > > >Meperidine > > > >Serious, sometimes fatal reactions have been precipitated with >concomitant use of meperidine (e.g., Demerol and other tradenames) >and MAO inhibitors including selective MAO-B inhibitors. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A330CD11-BFD0-4079-A8F7-DF8EABB477B4>CONTRAINDICATIONS). > > > >Dextromethorphan > > > >The concomitant use of AZILECT and dextromethorphan was not allowed >in clinical studies. The combination of MAO inhibitors and >dextromethorphan has been reported to cause brief episodes of >psychosis or bizarre behavior. Therefore, in view of AZILECT's MAO >inhibitory activity, dextromethorphan should not be used >concomitantly with AZILECT. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A330CD11-BFD0-4079-A8F7-DF8EABB477B4>CONTRAINDICATIONS). > > > >Sympathomimetic Medications > > > >The concomitant use of AZILECT and sympathomimetic medications was >not allowed in clinical studies. Severe hypertensive reactions >have followed the administration of sympathomimetics and >non-selective MAO inhibitors. One case of hypertensive crisis has >been reported in a patient taking the recommended doses of a >selective MAO-B inhibitor and a sympathomimetic medication >(ephedrine). Therefore, in view of AZILECT's MAO inhibitory >activity, AZILECT should not be used concomitantly with >sympathomimetics including nasal and oral decongestants and cold >remedies. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A330CD11-BFD0-4079-A8F7-DF8EABB477B4>CONTRAINDICATIONS >and ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A4D59127-FA1F-4D69-8CC5-5CCFC5FDC42D>WARNINGS, >Need for Restriction of Dietary Tyramine and Amines Contained in Medications). > > > >MAO Inhibitors > > > >AZILECT should not be administered along with other MAO inhibitors >because of the increased risk of non-selective MAO inhibition that >may lead to a hypertensive crisis. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A330CD11-BFD0-4079-A8F7-DF8EABB477B4>CONTRAINDICATIONS). > > > >Selective Serotonin Reuptake Inhibitors (SSRIs), Tricyclic and >Tetracyclic Antidepressants > > > >Concomitant use of SSRI, tricyclic, and tetracyclic antidepressants >with AZILECT is not recommended. (See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A54FBD8C-670C-4E03-BAC2-71BF546F37AF>WARNINGS). > > > >Levodopa/carbidopa > > > >(See ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A65301C1-C288-4F47-9D4D-C004DA17BB2E>CLINICAL >PHARMACOLOGY, Drug-Drug Interactions; ><http://dailymed.nlm.nih.gov/dailymed/archives/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11322#A5A90675-7928-4A07-A595-FB6FF5842DCD>PRECAUTIONS, >General, Dyskinesias Due to Levodopa Treatment ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn