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I took Sinemet, Sinemet CR and Baclofen 4 times each day spaced 5-6 hours apart. Then Dystonia started to demand more 'something' so after consulting with my Neurologist I added another 1/2 dose of Baclofen and amended my schedule for it accordingly, making the timing awkward. I also take Lyrica, Amantadine and Selegiline 2 each per day, one each with my "morning" dose and one with my "suppertime" dose. Here's my question. When symptoms increase such as Dystonia or tremor is one better off increasing one or more of the doses and leaving the intervals between doses the same or adding a dose and decreasing the intervals. For example, I could add a dose of two regular Sinemet capsules and decrease the intervals to 4 hours taking 5 doses instead of 4 or I could add 1/2 tablet of Sinemet to each of the current four doses. When I re-read this I'm not sure I haven't mangled it. If not and you have an opinion or experience I would appreciate hearing it ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn