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John Y, I have understood Stalevo to be a combination of carbidopa/levidopa and Comtan. I also understand that it will help to bridge your off-times, or fill in the valleys in the effectiveness curve of your Sinemet, if you will. I was diagnosed in 2001 at age 47, and I would say I've slowed, but still I try to be as active as I can. My #1 complaint is fatigue and tremor. I currently take 100 mg Stalevo 3 times a day, and have been taking it for a few years now, and I am tolerating it pretty well. I also take Sinemet ER 50/200 three times a day. After an uptick in symptoms this year, I asked my neuro, and he increased the dosage of Stalevo to 150 mg. This caused a marked increase in dyskenesia. Since I like dyskenesia about as well as fava beans (not at all), I went back to 100 mg of Stalevo and will be satisfied with that. Any other drug that I've tried, including Selegiline, has made me almost fatally sleepy, meaning my drugs caused me to fall asleep behind the wheel in mid-afternoon. Since then I have minimized my intake of PD drugs, and quit a couple of them. I suggest you be very cautious in your activities when starting any new PD drug, especially when you're doing something that requires you to be conscious! Good luck! Rick McGirr -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]] On Behalf Of JOHN YOCHIM Sent: Thursday, November 10, 2011 4:46 PM To: [log in to unmask] Subject: COMTAN & AZILECT I was diagnosed with PD in 2005. Im currently 67 and active. I take Sinemet 3 x day / 2 tabs each time. My Neuro is thinking that either Azilect (rasagiline) or Comtan (also known as Stalevo) might help me with some of my symptoms. My symptoms are the usual// /tremor/gait/stiffness/fatigue etc. My question is: what, if any, experiences have you had with one or the other medication I would appreciate any feedback that you might have. I have read the effect/side effects listed and would like to hear from those that have taken the med. Thank you for your time and help. John Y. Erie, Pennsylvania ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn