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Hi John, I have not used Apokyn (Apomorphine here in the UK) but do know a couple of people who have used it, in both cases the beneficial effect of the Apokyn were almost instant, but only lasted approx 20 minutes, and were followed by very severe side effects, flailing arms and legs and writhing body and neck lasting at least half an hour. I made a mental note to myself that this is one medication to avoid. 
As for fast acting medication, I use Madopar 187.5mg  ( Sinemet ) dispersible tablets four times a day, these generally "kick in" after 10 to 20 minutes, compared to normal Madopar capsules which took half an hour or more to "kick in".
As for Amantadine, I used this for several years, but I was unsure whether or not it was having any beneficial effects.
All of the above observations and comments are my experiences, and will not necessarily apply to you or any other PD sufferer.  
Regards,
 
Nigel Harland
Diagnosed 1989
From: John Bianchi <[log in to unmask]>
To: [log in to unmask] 
Sent: Thursday, 26 December 2013, 21:20
Subject: Anyone familiar with treating PD of Apokyn ?


I am currently on 7 doses a day of 125 mg of Stalevo (one dose every 3 hrs) which allows me to remain basicall  "on" for a full work work day as a teacher with a barely tolerable amount of dyskinesea (bouncing left leg).  We have tried treating the dyskinesea with Amantadine but have had minimal success.  I would like to reduce the dosage of Stalevo but I've had a few crippling dystonia bouts during off-periods at lower dosages.  In my case the dystonia hits my good side shoulder and leg muscles, causing painful contractions making it near impossible to walk (much less drive).

My neurologist suggested the use of Apokyn self-administered shots for combatting the dystonia.  The major side of effect of nausea and the fact that it is a dopamine agonist are making me question this approach.  

Has anyone out there had experience with Apokyn ?

How about any other fast acting medicine to get me out of a dystonia -induced "Freesure" (as my neurologist) calls it ?


Thank you in advance for your time.

John Bianchi
(diagnosed about ~6 years ago)


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