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thanks Roger, suggestions sound helpful -----Original Message----- From: Roger Seymour Sent: Wednesday, February 12, 2014 4:13 PM To: [log in to unmask] Subject: Re: mouse speed Another way to deal with mouse issues is to not use it... the mouse, that is. Yes, easier said than done, as many web pages are optimized for mouse use. But, here are a few tips (in the Windows environment prior to Windows 8): - Use your Tab button. On most web pages, you can move around the page by pushing Tab or Shift-Tab. For example, let's say you are filling out a registration and need to type in name, address, etc. If the page is properly designed, each time you press Tab the cursor will advance to the next logical location on the screen. So, if the form on the screen has a cell for First Name then a cell for Last Name, once you've typed in your first name you press Tab and the cursor will be placed at the start of the Last Name cell. No mouse clicks required. (BTW - Shift-Tab reverses the direction) - Don't click on the Login button. Say you're logging into a secure site: if the page is well designed, the cursor will initially appear in the Login Name cell. You type in your login name and then hit Tab - the cursor is now in the Password cell. You type your password then press ENTER. The code will, in most cases, interpret this keystroke the same as if you clicked on the Login button. Again, no clicks required. - Use keyboard shortcuts. Every major application that I've used has some associated keyboard shortcuts. These are typically combinations of keys like CTRL-C (copy selection) which is achieved by pressing and holding the CTRL button before pressing the C button. For example, CTRL-P is an (almost) universal shortcut for "Print". ALT-F4 closes the current application. CTRL-S saves the updates to the file you're working on. Virtually every menu selection has an associated shortcut, some more useful than others. One of my "Rules of Computers" is: Make enough dumb mistakes and you WILL discover something useful. I've discovered a number of highly useful shortcuts by just this method. Cheers. Roger -----Original Message----- From: Rayilyn Brown Sent: Thursday, January 30, 2014 1:07 PM To: [log in to unmask] Subject: mouse speed Amanda, we've already adjusted for mouse speed. Its me not the mouse. my "fine motor skills" are nonexistent. -----Original Message----- From: A Phillips Sent: Wednesday, January 29, 2014 4:21 PM To: [log in to unmask] Subject: Re: ProSavin gene therapy It should be possible if fiddly to adjust the way the mouse reacts, eg make it less or more movement-sensitive. You might also find a bigger mouse easier (or even a smaller one if like me you have small hands). > Date: Mon, 27 Jan 2014 09:16:47 -0500 > From: [log in to unmask] > Subject: Re: ProSavin gene therapy > To: [log in to unmask] > > You are doing just fine posting all sorts of important information for > PWP. > Good for you, Ray. We all depend upon you so just keep on keeping on. :-) > --------- > Mary Ann > ----- Original Message ----- > From: "Rayilyn Brown" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Sunday, January 26, 2014 7:10 PM > Subject: Re: ProSavin gene therapy > > > > Mary Ann > > > > Great you have such close family!! Medical clinic sounds interesting. > > > > I haven't down such a good job of posting since my research buddy, > > Diane, > > died over two years ago. also my computer does some strange things > > when I move the mouse and "click". Its harder to cut and paste now, > > but > > I hope I won't miss real news. > > > > -----Original Message----- > > From: Mary Ann Ryan > > Sent: Friday, January 24, 2014 7:46 AM > > To: [log in to unmask] > > Subject: Re: ProSavin gene therapy > > > > Ray, life is good here. Jamie continues to be a part of our lives - my > > grandkids sit in his recliner more than in any other furniture in the > > house > > so I think they feel his sweet presence. I volunteer once a week at a > > homeless shelter - I run a medical clinic there. We still have the > > farm > > and continue to plant a huge garden every year. My daughter and her > > husband > > plus their two kids live with me so I never feel alone. My son and > > daughter-in-law visit frequently. > > > > It's good to see that you still are active in informing PWP about > > studies > > and the need for advocacy. Thanks for all that you do. > > -------- > > Mary Ann > > ----- Original Message ----- > > From: "Rayilyn Brown" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Thursday, January 23, 2014 2:20 PM > > Subject: Re: ProSavin gene therapy > > > > > >> you're welcome, Mary Ann. How are you doing? > >> > >> -----Original Message----- > >> From: Mary Ann Ryan > >> Sent: Wednesday, January 22, 2014 7:31 AM > >> To: [log in to unmask] > >> Subject: Re: ProSavin gene therapy > >> > >> Thanks, Ray. This is great information and I plan on saving it for > >> future > >> use. It is frustrating that a miracle therapy is not on the horizon > >> but > >> at > >> least you got the attention of this doctor so that the PD community can > >> be > >> better informed. Thank you so much for your effort. > >> ------- > >> Mary Ann (CG Jamie 68/28 with PD, died 11/20/07) > >> > >> > >> > >>> Dear Rayilyn, > >>> > >>> I perfectly understand your current situation. Although I have been > >>> trained as MD, I have never treated patients since I am engaged 100% > >>> in > >>> PD research. I am in close contact with the Spanish association of > >>> Parkinson's disease, and I strongly feel that one of my obligations is > >>> to explain the patients what's going on in PD research. I know that it > >>> is fustrating to see that anything new has arrived in the past few > >>> years, besides some minor improvements in dopamine-replacement > >>> therapies > >>> (if I am right, a phase 2 trial testing an inhaled preparation of > >>> levodopa is going to start soon in US). When attending scientific > >>> meetings, the overall feeling is that everybody is always moving > >>> around > >>> the same topics, without any real new improvement or any real new > >>> ideas > >>> to follow. In this regard, gene-based therapies such as ProSavin at > >>> least represent something different. I cannot anticipate how long will > >>> it take to see these new arrivals fully available in the market as a > >>> therapeutic tool. Nevertheless, I still thinking that approaches this > >>> kind at least represent something different, and I am sure that this > >>> is > >>> a right step in the right direction. In the past two years my group > >>> has > >>> received some EU funding to start testing different approaches of gene > >>> therapy for manipulating basal ganglia circuits. We are using > >>> MPTP-treated monkeys since these represent the best animal model > >>> available so far, and working with monkeys speeds up the time required > >>> to start testing new tools in humans suffering from PD. I can give you > >>> my word that we are working very hard trying to generate the expected > >>> results asap. We have just started several experiments, all very risky > >>> approaches, and therefore I cannot anticipate any final result. > >>> Nevertheless, you can be sure that the situation of PD patients always > >>> is very well represented in my mind at all times. > >>> > >>> I know that it is not easy to be optimistic in the current scenario. > >>> However, my personal feeling is that testing some new research avenues > >>> has just been started. There is too much pressure to go traslational, > >>> and to start testing new approaches in patients asap. This pressure > >>> implies that some promising things enter clinical trials too early, > >>> and > >>> therefore it is fustrating to see that most of these new therapies > >>> failed in clinical trials. Just simply remember the failures of GDNF > >>> and > >>> nurturin. These are very good examples of promising things that failed > >>> because by the time these get tested in humans, we knew very little > >>> about their function. For instance, by the time in which GDNF entered > >>> phases 1-2 (the "Kentucky" and "Bristol" trials), we didn't knew too > >>> much about the neurobiology of GDNF. Researches we have to deal with > >>> this pressure, that's life. However, my feeling is that we cannot > >>> generate any solid expectances for PD patients without a clear > >>> proof-of-principle. As I have mentioned before, some failures we have > >>> seen in the past easily rank within this category of things being > >>> tested > >>> too early. > >>> > >>> According to the published results from ProSavin, this might not be > >>> seen > >>> as the way to go. My opinion is just the opposite. Although I will > >>> have > >>> been delighted to see a better clinical outcome, the important > >>> argument > >>> of ProSavin is that approaches this kind at least opens new vistas in > >>> PD > >>> research. I can perfectly understand that you are tired of getting > >>> worse > >>> and waiting. I just can tell you that everything that me -and many > >>> others- we are currently doing is done bearing in mind at all times > >>> the > >>> clinical situation of thousands of PD patients. You are our main > >>> motivation, and this is how things should be. Of course I cannot > >>> promise > >>> any miracle, just a tireless effort in PD research, every day. > >>> > >>> All the best and have a nice day, Jose L. Lanciego > >>> > >>> Rayilyn Brown escribió: > >>>> Jose > >>>> > >>>> I've had PD 18 years, have gotten worse, am 78 years old and fear at > >>>> the present pace of research will not live long enough to benefit > >>>> from > >>>> any of the 'promising" treatments on the horizon. I'm tired of > >>>> getting > >>>> worse and waiting. But then I'm anemic, maybe that’s it. > >>>> > >>>> -----Original Message----- From: José Luis Lanciego > >>>> Sent: Tuesday, January 21, 2014 3:06 AM > >>>> To: [log in to unmask] > >>>> Subject: Re: ProSavin gene therapy > >>>> > >>>> Dear Rayilyn, > >>>> > >>>> I guess this is not discouraging at all. Although this is a > >>>> preliminary > >>>> study, my feeling is that ProSavin represents a right step in the > >>>> right > >>>> direction. A number of gene therapy experiments are currently > >>>> undergoing > >>>> and we will see what's coming out in the next few years. Indeed, this > >>>> approach -and few more under experimental implementation- is > >>>> something > >>>> different, e.g., it is not based on dopamine-replacement strategies. > >>>> My > >>>> laboratory -as many others- strongly feels that many new arrivals can > >>>> be > >>>> expected from gene therapy experiments, with the ultimate goal of > >>>> using > >>>> gene therapy tools to manipulate basal ganglia circuits. Compared to > >>>> cell therapies, gene therapy seems to be a much more feasible and > >>>> realistic strategy. > >>>> > >>>> All the best and have a nice day, Jose L. Lanciego > >>>> > >>>> Rayilyn Brown escribió: > >>>>> discouraging isn't it? > >>>>> > >>>>> -----Original Message----- From: Nic Marais > >>>>> Sent: Saturday, January 18, 2014 12:29 AM > >>>>> To: [log in to unmask] > >>>>> Subject: Re: ProSavin gene therapy > >>>>> > >>>>> When you read the Viartis notification, it does not look as positive > >>>>> as > >>>>> this article... > >>>>> > >>>>> http://www.viartis.net/parkinsons.disease/news/140113.htm > >>>>> > >>>>> Nic 61/19 > >>>>> > >>>>> > >>>>> On 17 January 2014 21:18, Rayilyn Brown <[log in to unmask]> wrote: > >>>>> > >>>>>> http://www.domain-b.com/technology/Health_Medicine/20140115_patients.html > >>>>>> > >>>>>> Ray > >>>>>> Rayilyn > >>>>>> Past Director AZNPF > >>>>>> Arizona Chapter National Parkinson Foundation > >>>>>> > >>>>>> ---------------------------------------------------------------------- > >>>>>> To sign-off Parkinsn send a message to: mailto: > >>>>>> [log in to unmask] > >>>>>> In the body of the message put: signoff parkinsn > >>>>>> > >>>>> > >>>>> ---------------------------------------------------------------------- > >>>>> To sign-off Parkinsn send a message to: > >>>>> mailto:[log in to unmask] > >>>>> In the body of the message put: signoff parkinsn > >>>>> ---------------------------------------------------------------------- > >>>>> To sign-off Parkinsn send a message to: > >>>>> mailto:[log in to unmask] > >>>>> In the body of the message put: signoff parkinsn > >>>>> > >>>> > >>>> ---------------------------------------------------------------------- > >>>> To sign-off Parkinsn send a message to: > >>>> mailto:[log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> ---------------------------------------------------------------------- > >>>> To sign-off Parkinsn send a message to: > >>>> mailto:[log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: > >>> mailto:[log in to unmask] > >>> In the body of the message put: signoff parkinsn > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn