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I have been taking Rytary now for about a month, so am relatively new to it. I was not having much luck with various combinations of immediate-release (IR) Sinemet and CR Sinemet at staying in the "on band" between tremors and stiffness (low side) and dyskinesias (high side). I'm still definitely in the "adjustment" stages with Rytary, currently taking three capsules of the 61.25/245 in the morning and mid-day and two capsules late afternoon. Generally, it takes 20-30 minutes to feel the effects of the new dose, followed by an "on" time of a couple of hours or so (depending on the day), then a fall-off period during which the tremors start to re-appear. Then, of course, I start it all again. The challenge I have is the timing of successive doses. It appears that, at the 4 to 4 1/2 hour dosing intervals that I have been using (and had used with the Sinemet IR/CR regimen) that the "flood" of levodopa that occurs when the first Rytary capsules dissolve is causing dystonias - contractions in legs and arms that start about 15 to 20 minutes after taking a new dose and last 30 to 45 minutes, not debilitating, but they really mess with my walking. They are distinct from the dyskinesias experienced later in the dosing period if I've taken too much (this is why I take only 2 capsules late afternoon, for example). So, I'm experimenting with extending the dosing interval some and/or staggering ingestion of the capsules. Overall, I seem to be experiencing a longer "on" time, fewer dyskinesias and less variability (lower peaks, shallower troughs) than with the IR/CR. I've found a good article on dosing of Rytary ( http://www.parkinson.org/NationalParkinsonFoundation/files/44/44a37611-7834-4eec-9a8b-c52ed3d4ab34.pdf), and there is more for the interested reader upon googling "pharmacokinetics of Rytary". Cheers! Roger On Thu, Jun 11, 2015 at 6:09 PM, A Phillips <[log in to unmask]> wrote: > I wonder if the blood /brain barrier varies in density - maybe the drugs > never get to your brain. > > > > I've got so many drugs in me at the moment my brain is probably pickled. > My urine is a weird bright orange. > > For me they work nicely for a few weeks then the effectiveness fades > (except the Amanta,dine which did nothing except possibly make ne throw up). > > Amanda. > > > > Date: Wed, 10 Jun 2015 23:16:26 -0700 > > From: [log in to unmask] > > Subject: Re: Rytary > > To: [log in to unmask] > > > > Tony > > > > the ratios of carbo to levo aare different in Rytary than in SInemet. I > > take 1 Rytary daily cause at the usual 3 side effects are a problem. I > > also take 2 Isradipine (BP drug in PD trial) daily. I dont think it helps > > much but it doesn’t hurt either. PD drugs have never really helped me. > > > > You just have to try drugs. > > > > -----Original Message----- > > From: AW Adler > > Sent: Wednesday, June 10, 2015 11:34 AM > > To: [log in to unmask] > > Subject: Rytary > > > > My wife's neurologist has suggested she switch from Sinemet to Rytary. > > Does anyone have any experience with the drug? I know it is fairly new > > to the market and as far as I can tell from the literature just Sinemet > > in delayed release capsules. > > Tony CG for Donna > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn