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Hi Roger! Thanks for the very useful information and document. It will certainly assist many of us. I will try Rytary as soon as it's available here (South Africa). Nic 63/21 On 12 June 2015 at 16:20, Ruellene and Roger Seymour <[log in to unmask]> wrote: > I have been taking Rytary now for about a month, so am relatively new to > it. I was not having much luck with various combinations of > immediate-release (IR) Sinemet and CR Sinemet at staying in the "on band" > between tremors and stiffness (low side) and dyskinesias (high side). I'm > still definitely in the "adjustment" stages with Rytary, currently taking > three capsules of the 61.25/245 in the morning and mid-day and two capsules > late afternoon. Generally, it takes 20-30 minutes to feel the effects of > the new dose, followed by an "on" time of a couple of hours or so > (depending on the day), then a fall-off period during which the tremors > start to re-appear. Then, of course, I start it all again. The challenge > I have is the timing of successive doses. It appears that, at the 4 to 4 > 1/2 hour dosing intervals that I have been using (and had used with the > Sinemet IR/CR regimen) that the "flood" of levodopa that occurs when the > first Rytary capsules dissolve is causing dystonias - contractions in legs > and arms that start about 15 to 20 minutes after taking a new dose and last > 30 to 45 minutes, not debilitating, but they really mess with my walking. > They are distinct from the dyskinesias experienced later in the dosing > period if I've taken too much (this is why I take only 2 capsules late > afternoon, for example). So, I'm experimenting with extending the dosing > interval some and/or staggering ingestion of the capsules. Overall, I seem > to be experiencing a longer "on" time, fewer dyskinesias and less > variability (lower peaks, shallower troughs) than with the IR/CR. > > I've found a good article on dosing of Rytary ( > > http://www.parkinson.org/NationalParkinsonFoundation/files/44/44a37611-7834-4eec-9a8b-c52ed3d4ab34.pdf > ), > and there is more for the interested reader upon googling "pharmacokinetics > of Rytary". > > Cheers! > > Roger > > On Thu, Jun 11, 2015 at 6:09 PM, A Phillips <[log in to unmask]> > wrote: > > > I wonder if the blood /brain barrier varies in density - maybe the drugs > > never get to your brain. > > > > > > > > I've got so many drugs in me at the moment my brain is probably pickled. > > My urine is a weird bright orange. > > > > For me they work nicely for a few weeks then the effectiveness fades > > (except the Amanta,dine which did nothing except possibly make ne throw > up). > > > > Amanda. > > > > > > > Date: Wed, 10 Jun 2015 23:16:26 -0700 > > > From: [log in to unmask] > > > Subject: Re: Rytary > > > To: [log in to unmask] > > > > > > Tony > > > > > > the ratios of carbo to levo aare different in Rytary than in SInemet. I > > > take 1 Rytary daily cause at the usual 3 side effects are a problem. I > > > also take 2 Isradipine (BP drug in PD trial) daily. I dont think it > helps > > > much but it doesn’t hurt either. PD drugs have never really helped me. > > > > > > You just have to try drugs. > > > > > > -----Original Message----- > > > From: AW Adler > > > Sent: Wednesday, June 10, 2015 11:34 AM > > > To: [log in to unmask] > > > Subject: Rytary > > > > > > My wife's neurologist has suggested she switch from Sinemet to Rytary. > > > Does anyone have any experience with the drug? I know it is fairly new > > > to the market and as far as I can tell from the literature just Sinemet > > > in delayed release capsules. > > > Tony CG for Donna > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: mailto: > > [log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: mailto: > > [log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto: > > [log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn